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Titolo:
The effect of [Phe(1)psi(CH2-NH)Gly(2)]-nociceptin(1-13)NH2 on feeding andc-Fos immunoreactivity in selected brain sites
Autore:
Olszewski, PK; Grace, MK; Billington, CJ; Levine, AS;
Indirizzi:
Vet Affairs Med Ctr, Res Serv, Minnesota Obes Ctr, Minneapolis, MN 55417 USA Vet Affairs Med Ctr Minneapolis MN USA 55417 r, Minneapolis, MN 55417 USA Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 pt Med, Minneapolis, MN 55455 USA Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 ychiat, Minneapolis, MN 55455 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 876, anno: 2000,
pagine: 95 - 102
SICI:
0006-8993(20000908)876:1-2<95:TEO[OF>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR GENE FAMILY; RAT SPINAL-CORD; ORPHANIN-FQ; NOCICEPTIN RECEPTOR; ORL1 RECEPTOR; TISSUE DISTRIBUTION; FEMALE RATS; AGONIST; ANTAGONIST; NEURONS;
Keywords:
c-Fos; feeding; nociceptin/orphanin FQ; naloxone; [Phe(1)psi(CH2NH)Gly(2)]nociceptin(1-13)-NH2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Levine, AS Vet Affairs Med Ctr, Res Serv, Minnesota Obes Ctr, 151, Minneapolis, MN 55417 USA Vet Affairs Med Ctr 151 Minneapolis MN USA 55417 , MN 55417 USA
Citazione:
P.K. Olszewski et al., "The effect of [Phe(1)psi(CH2-NH)Gly(2)]-nociceptin(1-13)NH2 on feeding andc-Fos immunoreactivity in selected brain sites", BRAIN RES, 876(1-2), 2000, pp. 95-102

Abstract

Nociceptin/orphanin FQ (N/OFQ) is an endogenous ligand of the ORL1 receptor. N/OFQ, when administered centrally, stimulates feeding in a fashion similar to other opioids. Intracerebroventricular administration of N/OFQ induces changes in c-Fos immunoreactivity in several feeding-related brain sites. A synthetic pseudopeptide, [Phe(1) i(CH2-NH)Gly(2)]-nociceptin(1-13)-NH2 (hereafter: [FG]N/OFQ(1-13)NH2), has been labeled both as an ORL1 agonist and antagonist. The present study was designed to examine the influence of [FG]N/OFQ(1-13)NH2 on food intake in rats. We also evaluated c-Fos immunoreactivity in those areas of the brain which have been shown to exhibit altered c-Fos expression upon N/OFQ administration. We found that [FG]N/OFQ(1-13)NH2 increases food consumption in satiated rats. This effect is short-lasting and can be reversed by the opioid antagonist naloxone. Go-administrationof [FG]N/OFQ(1-13)NH2 does not affect orexigenic response to N/OFQ. Intracerebrovenrricularly-injected [FG]N/OFQ(1-13)NH2 induces c-Fos expression inthe nucleus of the solitary tract, hypothalamic paraventricular and supraoptic nuclei, central nucleus of amygdala, lateral septal and lateral habenular nuclei-brain areas that have been shown to be activated by N/OFQ. Theseresults support the hypothesis that [FG]N/OFQ(1-13)NH2 acts as an agonist of ORL1 receptor in vivo. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:27:38