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Titolo:
Multiple opioid receptors mediate feeding elicited by mu and delta opioid receptor subtype agonists in the nucleus accumbens shell in rats
Autore:
Ragnauth, A; Moroz, M; Bodnar, RJ;
Indirizzi:
CUNY Queens Coll, Dept Psychol, Flushing, NY 11367 USA CUNY Queens Coll Flushing NY USA 11367 pt Psychol, Flushing, NY 11367 USA CUNY Queens Coll, Neuropsychol Doctoral Subprogram, Flushing, NY 11367 USACUNY Queens Coll Flushing NY USA 11367 Subprogram, Flushing, NY 11367 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 876, anno: 2000,
pagine: 76 - 87
SICI:
0006-8993(20000908)876:1-2<76:MORMFE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; NOR-BINALTORPHIMINE; FOOD-INTAKE; GLUTAMATE RECEPTORS; OPIATE RECEPTORS; DOPAMINE RELEASE; CELLULAR SITES; NALTRINDOLE 5'-ISOTHIOCYANATE; DIFFERENTIAL ANTAGONISM; DECREASES DEPRIVATION;
Keywords:
feeding; nucleus accumbens shell; mu opioid receptor; mu(1) opioid receptor; delta(1) opioid receptor; delta(2) opioid receptor; kappa(1) opioid receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Bodnar, RJ CUNY Queens Coll, Dept Psychol, 65-30 Kissena Blvd, Flushing, NY 11367 USA CUNY Queens Coll 65-30 Kissena Blvd Flushing NY USA 11367 7 USA
Citazione:
A. Ragnauth et al., "Multiple opioid receptors mediate feeding elicited by mu and delta opioid receptor subtype agonists in the nucleus accumbens shell in rats", BRAIN RES, 876(1-2), 2000, pp. 76-87

Abstract

The nucleus accumbens, and particularly its shell region, is a critical site at which feeding responses can be elicited following direct administration of opiate drugs as well as mu-selective and delta-selective, but not kappa-selective opioid receptor subtype agonists. In contrast to observations of selective and receptor-specific opioid antagonist effects upon corresponding agonist-induced actions in analgesic studies, ventricular administration of opioid receptor subtype antagonists blocks feeding induced by multiple opioid receptor subtype agonists. The present study examined whether feeding responses elicited by either putative mu ([D-Ala(2), NMe-Phe(4), Gly-ol(5)]-enkephalin (DAMGO)), delta(1) ([D-Pen(2), D-Pen(5)]-enkephalin (DPDPE)) or delta(2) ([D-Ala(2), Glu(4)]-deltorphin (Deltorphin)) opioid receptor subtype agonists administered into the nucleus accumbens shell were alteredby accumbens pretreatment with either selective mu (beta-funaltrexamine), mu(1), (naloxonazine), delta(1) ([D-Ala(2), Leu(5), Cys(6)]-enkephalin (DALCE)), delta(2) (naltrindole isothiocyanate) or kappa(1) (nor-binaltorphilmine) opioid receptor subtype antagonists. Similar magnitudes and durations of feeding responses were elicited by bilateral accumbens administration of either DAMGO (2.5 mu g), DPDPE (5 mu g) or Deltorphin (5 mu g). DAMGO-induced feeding in the nucleus accumbens shell was significantly reduced by accumbens pretreatment of mu, delta(1), delta(2) and kappa(1), but not mu(1), opioid receptor subtype antagonists. DPDPE-induced feeding in the accumbens was significantly reduced by accumbens pretreatment of mu, delta(1), delta(2) and kappa(1). but not mu(1) opioid receptor subtype antagonist. Deltorphin-induced feeding in the accumbens was largely unaffected by accumbens delta(2) antagonist pretreatment, and was significantly enhanced by accumbens mu or kappa(1) antagonist pretreatment. These data indicate different opioid pharmacological profiles fur Feeding induced by putative mu, delta(1) anddelta(2) opioid agonists in the nucleus accumbens shell, as well as the participation of multiple opioid receptor subtypes in the elicitation and maintenance of feeding by these agonists in the nucleus accumbens shell. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:50:10