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Titolo:
Higher natural killer cell activity in schizophrenic patients: The impact of serum factors, medication, and smoking
Autore:
Yovel, G; Sirota, P; Mazeh, D; Shakhar, G; Rosenne, E; Ben-Eliyahu, S;
Indirizzi:
Tel Aviv Univ, Dept Psychol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 sychol, IL-69978 Tel Aviv, Israel Y Abarbanel Mental Hlth Ctr, Bat Yam, Israel Y Abarbanel Mental Hlth Ctr Bat Yam Israel al Hlth Ctr, Bat Yam, Israel Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel v Univ, Sackler Fac Med, Tel Aviv, Israel
Titolo Testata:
BRAIN BEHAVIOR AND IMMUNITY
fascicolo: 3, volume: 14, anno: 2000,
pagine: 153 - 169
SICI:
0889-1591(200009)14:3<153:HNKCAI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LARGE GRANULAR LYMPHOCYTES; NK CELLS; INTERLEUKIN-2 PRODUCTION; METASTATIC SPREAD; TUMOR-METASTASIS; DISEASE; RATS; CANCER; IMMUNITY; INVIVO;
Keywords:
natural killer cells; schizophrenia; cytokines; cancer; smoking; neuroleptics; dopamine; whole blood assay;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Yovel, G Tel Aviv Univ, Dept Psychol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 L-69978 Tel Aviv, Israel
Citazione:
G. Yovel et al., "Higher natural killer cell activity in schizophrenic patients: The impact of serum factors, medication, and smoking", BRAIN BEH, 14(3), 2000, pp. 153-169

Abstract

Schizophrenia has been associated with altered immunity and reduced occurrence of autoimmune diseases and malignancies. A few studies in schizophrenic patients have assessed natural killer cell activity (NKA), but no consistent findings have emerged. However. NKA was assessed using standard procedures and in the absence of autologous serum and the various cytokines that modulate NKA and appear to be abnormal in schizophrenic patients. In the current study, therefore, the number of NK cells and the activity of the individual NK cell were assessed in whole blood shortly after blood withdrawal, in both the presence and the absence of autologous serum. Twenty-nine schizophrenic patients (11 nonmedicated), 8 nonschizophrenic control patients (bipolar and personality disorders), and 31 age-matched healthy controls werestudied. Schizophrenic patients showed higher NKA per NK cell than controls and nonschizophrenic patients. This difference remained significant even when the nonmedicated schizophrenics, who showed the highest levels of Nf(A, were excluded. However, the increase in NKA was more pronounced in the presence of serum and was reduced to an insignificant level when serum was removed From the same samples. In both schizophrenic patients and controls, smokers and women showed lower NKA. Numbers of NK cells did not differ amonggroups, although medication affected blood concentration of other leukocytes. These findings indicate that the effects of serum factors, psychiatric medication, gender, and smoking should be considered when assessing NKA in schizophrenic patients. The observed higher NKA may help explain the surprising reports of low incidence of lung cancer and other malignancies in schizophrenic patients, despite their higher rate of smoking. (C) 2000 AcademicPress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 08:03:07