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Titolo:
Object retrieval/detour deficits in monkeys produced by prior subchronic phencyclidine administration: Evidence for cognitive impulsivity
Autore:
Jentsch, JD; Roth, RH; Taylor, JR;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 , Dept Psychiat, New Haven, CT 06520 USA Yale Univ, Sch Med, Neurobiol Sect, New Haven, CT 06520 USA Yale Univ NewHaven CT USA 06520 Neurobiol Sect, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06520 USA Yale Univ NewHaven CT USA 06520 Dept Pharmacol, New Haven, CT 06520 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 5, volume: 48, anno: 2000,
pagine: 415 - 424
SICI:
0006-3223(20000901)48:5<415:ORDIMP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
REWARD-RELATED STIMULI; CARD SORT TEST; PREFRONTAL CORTEX; 6-HYDROXYDOPAMINE LESIONS; EXCITOTOXIC LESIONS; EXECUTIVE FUNCTIONS; CONDITIONED REWARD; INHIBITORY CONTROL; NUCLEUS-ACCUMBENS; WORKING-MEMORY;
Keywords:
inhibitory control; dopamine; prefrontal cortex; drug addiction; schizophrenia; animal model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, JR Yale Univ, Sch Med, Dept Psychiat, 333 Cedar St,POB 208068, NewHaven, CT 06520 USA Yale Univ 333 Cedar St,POB 208068 New Haven CT USA 06520 20 USA
Citazione:
J.D. Jentsch et al., "Object retrieval/detour deficits in monkeys produced by prior subchronic phencyclidine administration: Evidence for cognitive impulsivity", BIOL PSYCHI, 48(5), 2000, pp. 415-424

Abstract

Background: Impulsivity associated with frontal cortical dysfunction appears to be a direct consequence of chronic consumption of drugs of abuse, though few investigations in animals have attempted to directly address this issue. In this study the effects of repeated, intermittent administration ofa psychotomimetic drug of abuse, phencyclidine, on the acquisition and performance of a task sensitive to corticostriatal function was examined in nonhuman primates. Methods: Monkeys were repeatedly exposed to phencyclidine (0.3 mg/kg) twice daily for 14 days. Acquisition and performance on an object-retrieval detour task was subsequently examined for up to 28 days after drug withdrawal. Results: Animals treated with phencyclidine exhibited impaired acquisitionof the task. The performance of trials requiring inhibitory control (as opposed to solely sensory-guided responding) was specifically impaired by prior phencyclidine administration. impairments were found to be due to increased perseveration and barrier reaching. As is the case after frontal cortexablation, the behavioral deficits were particularly evident during acquisition and appeared to be alleviated by prolonged training. Conclusions: The current data demonstrate that subchronic administration of phencyclidine can produce deficits in inhibitory response control that are manifest as impulsivity (increased control of behavior by unconditioned, appetitive stimuli). These data suggest that long-term phencyclidine exposure induces frontostriatal-like cognitive impairments and may represent a potential (drug induced) model for the study of prefrontal cortical cognitiveand dopaminergic dysfunction. (C) 2000 Society of Biological Psychiatry.

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Documento generato il 09/04/20 alle ore 00:30:05