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Titolo:
Towards the prevention of schizophrenia
Autore:
Tsuang, MT; Stone, WS; Faraone, SV;
Indirizzi:
Harvard Univ, Massachusetts Mental Hlth Ctr, Dept Psychiat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Ctr, Dept Psychiat, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Psychiat, Brockton W Roxbury Vet Affairs Med Ctr, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 et Affairs Med Ctr, Boston, MA 02115 USA Massachusetts Gen Hosp, Psychiat Serv, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 iat Serv, Boston, MA 02114 USA Harvard Univ, Inst Psychiat Epidemiol & Genet, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 Epidemiol & Genet, Boston, MA 02114 USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 5, volume: 48, anno: 2000,
pagine: 349 - 356
SICI:
0006-3223(20000901)48:5<349:TTPOS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-LINE TREATMENT; NONPSYCHOTIC RELATIVES; WORKING-MEMORY; INTERVENTION; RISK; RISPERIDONE; RATIONALE; PSYCHOSIS; HETEROGENEITY; INDICATORS;
Keywords:
schizotaxia; genetics; negative symptoms; neuropsychology; risperidone;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuang, MT Harvard Univ, Massachusetts Mental Hlth Ctr, Dept Psychiat, 74 Fenwood Rd,Boston, MA 02115 USA Harvard Univ 74 Fenwood Rd Boston MA USA 02115 on, MA 02115 USA
Citazione:
M.T. Tsuang et al., "Towards the prevention of schizophrenia", BIOL PSYCHI, 48(5), 2000, pp. 349-356

Abstract

There is a growing emphasis on attempts to identify the early signs and symptoms of schizophrenia, largely because early detection and treatment of psychosis (i.e., secondary prevention) are associated with relatively favorable clinical outcomes. This raises the issue of whether prevention of psychosis itself is possible. The achievement of this goal will require the identification of a premorbid state that could serve as the foundation for treatment strategies aimed ultimately at the prevention of schizophrenia. Fortunately evidence for such a state is emerging, in part because schizophreniamay result from a neurodevelopmental disorder that is associated with a variety of clinical, neurobiological, and neuropsychologic features occurringwell before the onset of psychosis. These features may serve as both indicators of risk for subsequent deterioration and the foundation of treatment efforts. We reformulated Meehl's term schizotaxia to describe this liability and discuss here how its study could form the basis for future strategiesof prevention. We also include a description of our initial attempts to devise treatment protocols for schizotaxia. II is concluded that schizotaxia is a feasible concept on which to base prevention efforts, anal that treatment of adult schizotaxia may be among the next steps in the process. (C) 2000 Society of Biological Psychiatry.

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Documento generato il 02/04/20 alle ore 00:06:03