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Titolo:
The chicken genome contains no HMG1 retropseudogenes but a functional HMG1gene with long introns
Autore:
Lum, HK; Lee, KLD; Yu, G;
Indirizzi:
Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China Hong Kong Polytech Univ Kowloon Hong Kong Peoples R China eoples R China
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
fascicolo: 1-2, volume: 1493, anno: 2000,
pagine: 64 - 72
SICI:
0167-4781(20000907)1493:1-2<64:TCGCNH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOSOMAL PROTEIN HMG-1; HUMAN CDNA SEQUENCE; SINGLE COPY GENE; 3'-UNTRANSLATED REGION; NUCLEOTIDE-SEQUENCE; MULTIGENE FAMILY; RECOMBINANT HMG1; MESSENGER-RNA; DNA; BINDING;
Keywords:
high mobility group 1; chicken; retropseudogene; high mobility group 2; high mobility group 2a; high mobility group 4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, KLD Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China Hong Kong Polytech Univ Kowloon Hong Kong Peoples R China China
Citazione:
H.K. Lum et al., "The chicken genome contains no HMG1 retropseudogenes but a functional HMG1gene with long introns", BBA-GENE ST, 1493(1-2), 2000, pp. 64-72

Abstract

We have cloned the genomic sequence coding for the high mobility group 1 (HMG1) protein in chickens. Multiple sequence alignment shows that the chicken HMG1 gene is highly homologous to the human and the mouse HMG1 genes. The gene structure of chicken HMG1 is similar to that of the mouse and the human HMG1 genes, with the same exon-intron boundaries. However, in contrast to other avian genes that have shorter introns, the chicken HMG1 gene has introns that are twice as long as their mammalian homologues. In addition tothe functional. intron-containing HMG1 gene, all mammalian genomes containmore than 50 copies of HMG1 retropseudogenes each, while in the chicken genome there are no HMG1 retropseudogenes. This finding suggests that the HMG1 retropseudogenes arose in mammals after their divergence away from the birds. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:25:33