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Titolo:
Two distinct regions of loss on chromosome arm 4q in primary head and necksquamous cell carcinoma
Autore:
Shah, SI; Yip, L; Greenberg, B; Califano, JA; Chow, J; Eisenberger, CF; Lee, DJ; Sewell, DA; Reed, AL; Lango, M; Jen, J; Koch, WM; Sidransky, D;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Head & Neck Canc Res Div, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 es Div, Baltimore, MD 21205 USA
Titolo Testata:
ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
fascicolo: 9, volume: 126, anno: 2000,
pagine: 1073 - 1076
SICI:
0886-4470(200009)126:9<1073:TDROLO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR SUPPRESSOR GENES; CANCER; PROGRESSION; DELETION; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Sidransky, D Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Head & Neck Canc Res Div, 720 Rutland Ave,818 Ross Bldg, Baltimore, MD 21205 USA Johns Hopkins Univ 720 Rutland Ave,818 Ross Bldg Baltimore MD USA 21205
Citazione:
S.I. Shah et al., "Two distinct regions of loss on chromosome arm 4q in primary head and necksquamous cell carcinoma", ARCH OTOLAR, 126(9), 2000, pp. 1073-1076

Abstract

Objective: To more clearly define the frequency and the regions of chromosome arm 4q loss in head and neck squamous cell carcinoma. Design: A retrospective microsatellite analysis of DNA from previously microdissected primary tumor samples. Setting: Academic medical center. Patients and Methods: One hundred primary tumor samples from patients withhead and neck squamous cell carcinoma were analyzed for loss of heterozygosity on the long arm of chromosome 4. The Kaplan-Meier method was used to estimate survival for 97 patients for whom clinical data were available. TheCox proportional hazards model was used to compare survival, and logistic regression was used to search for associations between clinical tumor characteristics and 4q status. Results: Analysis of 33 polymorphic microsatellite markers identified 51 samples (51%) exhibiting loss of heterozygosity of 4q in at least 1 locus. Eighteen tumors revealed loss at all informative markers, indicating monosomy or complete deletion of 4q. Thirty-three tumors displayed partial loss ofheterozygosity and delineated 2 minimal areas of loss at 4q2324 and 4q2829. Eleven rumors displayed loss solely at the 4q2324 region, 13 tumors displayed deletions confined to the 4q2829 region, and 9 tumors displayed selective loss at both regions. A separate analysis in a subset of 94 primary head and neck tumors was done to further delineate the minimal area of chromosomal loss at 4q2324. Analysis of 8 markers in this region allowed us to identify the smallest region of loss between markers D4S2986 and D4S1564 (a distance of 2 centimorgans). Review of the clinical records of 97 patients revealed no statistically significant association between 4q status and any clinical variable, including survival. Conclusion: These results confirm a high frequency of chromosome arm 4q loss in primary head and neck squamous cell carcinoma and might demarcate 2 novel putative suppressor loci involved in progression of this carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:16:52