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Titolo:
Risk factors for advancement of cytomegalovirus retinitis in patients withacquired immunodeficiency syndrome
Autore:
Holbrook, JT; Davis, MD; Hubbard, LD; Martin, BK; Holland, GN; Jabs, DA; Gilpin, AK; Meinert, C; Reshef, DS;
Indirizzi:
Johns Hopkins Univ, Sch Med, Ctr Clin Trials, Dept Epidemiol, Baltimore, MD 21218 USA Johns Hopkins Univ Baltimore MD USA 21218 demiol, Baltimore, MD 21218 USA Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Baltimore, MD 21218 USA Johns Hopkins Univ Baltimore MD USA 21218 halmol, Baltimore, MD 21218 USA Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21218 USA Johns Hopkins Univ Baltimore MD USA 21218 pt Med, Baltimore, MD 21218 USA Univ Wisconsin, Fundus Photograph Reading Ctr, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 ph Reading Ctr, Madison, WI 53706 USA Univ Calif Los Angeles, Sch Med, Jules Stein Eye Inst, Ocular InflammatoryDis Ctr, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Dept Ophthalmol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
ARCHIVES OF OPHTHALMOLOGY
fascicolo: 9, volume: 118, anno: 2000,
pagine: 1196 - 1204
SICI:
0003-9950(200009)118:9<1196:RFFAOC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOPATHY; SUBSETS; MODELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Holbrook, JT 615 N Wolfe St,Room 5010, Baltimore, MD 21205 USA 615 N Wolfe St,Room 5010 Baltimore MD USA 21205 MD 21205 USA
Citazione:
J.T. Holbrook et al., "Risk factors for advancement of cytomegalovirus retinitis in patients withacquired immunodeficiency syndrome", ARCH OPHTH, 118(9), 2000, pp. 1196-1204

Abstract

Objective: To identify ocular and systemic factors that predict advancement of cytomegalovirus (CMV) retinitis during treatment. Methods: Patients with acquired immunodeficiency syndrome were enrolled ina multicenter clinical trial designed to evaluate foscarnet sodium and ganciclovir sodium as therapy for newly diagnosed CMV retinitis. Ocular characteristics at baseline and measurements of retinitis were assessed from fundus photographs by graders at a fundus photograph reading center. The following measures of advancement were assessed: (1) lesion border movement of atleast 750 mu m or development of a new lesion in involved eyes; (2) rate of increase in retinal area with CMV in involved eyes; and (3) development of retinitis in uninvolved eyes of patients with unilateral disease at baseline. Results: In eyes with retinitis, risk factors at baseline for advancement while receiving treatment included smaller area involved, active margins ofretinitis, and posterior location. Risk factors for development of retinitis in uninvolved fellow eyes included blood and urine cultures positive forCMV and lower CD8(+) T-lymphocyte count. Conclusions: Lesion characteristics can be used to predict advancement of preexisting disease, whereas only systemic factors are associated with development of bilateral disease. These analyses describe retinitis activity before the introduction of potent antiretroviral therapies but provide an important reference point for patients in whom CMV retinitis develops after failure or intolerance of antiretroviral agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:14:41