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Titolo:
The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitro
Autore:
Elattar, TMA; Virji, AS;
Indirizzi:
Univ Missouri, Sch Med & Dent, Hormone Res Lab, Kansas City, MO 64108 USA Univ Missouri Kansas City MO USA 64108 Res Lab, Kansas City, MO 64108 USA
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 3A, volume: 20, anno: 2000,
pagine: 1733 - 1738
SICI:
0250-7005(200005/06)20:3A<1733:TIEOCG>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-E SUCCINATE; HEAT-SHOCK PROTEIN; DIETARY CURCUMIN; MOUSE SKIN; ISOFLAVONE GENISTEIN; COLON CARCINOGENESIS; TOPICAL APPLICATION; TUMOR INITIATION; DNA-SYNTHESIS; JAPANESE MEN;
Keywords:
squamous cell carcinoma (SCC-25); oral cancer; cisplatin; curcumin; genistein; quercetin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Elattar, TMA Univ Missouri, Sch Med & Dent, Hormone Res Lab, Kansas City, MO 64108 USA Univ Missouri Kansas City MO USA 64108 as City, MO 64108 USA
Citazione:
T.M.A. Elattar e A.S. Virji, "The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitro", ANTICANC R, 20(3A), 2000, pp. 1733-1738

Abstract

Epidemiological evidence indicates that plant derived flavonoids and otherphenolic antioxidants protect against heart disease and cancer. In the current investigation utilizing human oral squamous carcinoma cell line (SCC-25), we have evaluated the potency of three different plant phenolics, viz.,curcumin, genistein and quercetin in comparison with that of cisplatin on growth and proliferation of SCC-25. Test agents were dissolved in DMSO and incubated in triplicates in 25 cm(2) flasks in DMEM- HAM's F-12 (50:50) supplemented with 10% calf serum and antibiotics in an atmosphere of 5% CO2 inair for 72 hours Cell growth was determined by counting the number of cells in a hemocytometer. Cell proliferation was determined by measuring DNA synthesis by the incorporation of [H-3]- thymidine in nuclear DNA. Cisplatin (0.1, 2.0, 10.0 mu M) and curcumin (0.1, 1.0, 10.0 mu M) induced significant dose-dependent inhibition in both cell growth as well as cell proliferation. Genistein and quercetin (1.0, 10.0, 100.0 mu M) had biphasic effect, depending on their concentrations, on cell growth as well as cell proliferation. Based on these findings, it is concluded that curcumin is considerably more patent than genistein and quercetin, but cisplatin is five fold more potent than curcumin in inhibition of growth and DNA synthesis in SCC-25.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:18:07