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Titolo:
Cellular copper transport and metabolism
Autore:
Harris, ED;
Indirizzi:
Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 iophys, College Stn, TX 77843 USA Texas A&M Univ, Fac Nutr, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 c Nutr, College Stn, TX 77843 USA
Titolo Testata:
ANNUAL REVIEW OF NUTRITION
, volume: 20, anno: 2000,
pagine: 291 - 310
SICI:
0199-9885(2000)20:<291:CCTAM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
WILSON-DISEASE GENE; ISOLATED RAT HEPATOCYTES; OCCIPITAL HORN SYNDROME; KINKY-HAIR SYNDROME; HUMAN K562 CELLS; P-TYPE ATPASES; MENKES-DISEASE; SACCHAROMYCES-CEREVISIAE; CANDIDATE GENE; SUPEROXIDE-DISMUTASE;
Keywords:
copper metabolism; Menkes gene; Wilson gene; Cu-transporting ATPase; copper chaperones; copper absorption;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
152
Recensione:
Indirizzi per estratti:
Indirizzo: Harris, ED Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 lege Stn, TX 77843 USA
Citazione:
E.D. Harris, "Cellular copper transport and metabolism", ANN R NUTR, 20, 2000, pp. 291-310

Abstract

The transport and cellular metabolism of Cu depends on a series of membrane proteins and smaller soluble peptides that comprise a functionally integrated system for maintaining cellular Cu homeostasis. Inward transport across the plasma membrane appears to be a function of integral membrane proteins that form the channels that select Cu ions for passage. Two membrane-bound Cu-transporting ATPase enzymes, ATP7A and ATP7B, the products of the Menkes and Wilson disease genes, respectively, catalyze an ATP-dependent transfer of Cu to intracellular compartments or expel Cu from the cell. ATP7A andATP7B work in concert with a series of smaller peptides, the copper chaperones, that exchange Cu at the ATPase sites or incorporate the Cu directly into the structure of Cu-dependent enzymes such as cytochrome c oxidase and Cu, Zn superoxide dismutase. These mechanisms come into play in response toa high influx of Cu or during the course of normal Cu metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:30:12