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Titolo:
Regulation of metabolism and body fat mass by leptin
Autore:
Baile, CA; Della-Fera, MA; Martin, RJ;
Indirizzi:
Univ Georgia, Dept Anim & Dairy Sci, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 t Anim & Dairy Sci, Athens, GA 30602 USA Univ Georgia, Dept Foods & Nutr, Athens, GA 30602 USA Univ Georgia AthensGA USA 30602 Dept Foods & Nutr, Athens, GA 30602 USA
Titolo Testata:
ANNUAL REVIEW OF NUTRITION
, volume: 20, anno: 2000,
pagine: 105 - 127
SICI:
0199-9885(2000)20:<105:ROMABF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; TUMOR-NECROSIS-FACTOR; CORTICOTROPIN-RELEASING HORMONE; BINDING-PROTEIN-ALPHA; WHITE ADIPOSE-TISSUE; OBESE GENE-PRODUCT; VENTROMEDIAL HYPOTHALAMIC-LESIONS; CENTRALLY ADMINISTERED LEPTIN; SYMPATHETIC NERVOUS-SYSTEM; RECOMBINANT MURINE LEPTIN;
Keywords:
energy balance; adipose tissue; obesity; food intake; nutrient flux;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
153
Recensione:
Indirizzi per estratti:
Indirizzo: Baile, CA Univ Georgia, Dept Anim & Dairy Sci, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 airy Sci, Athens, GA 30602 USA
Citazione:
C.A. Baile et al., "Regulation of metabolism and body fat mass by leptin", ANN R NUTR, 20, 2000, pp. 105-127

Abstract

The relative stability of body weight over the long term and under a variety of environmental conditions that alter short-term energy intake and expenditure provides strong evidence for the regulation of body energy content. The lipostatic theory of energy balance regulation proposed 40 years ago that circulating factors, generated in proportion to body fat stores, acted as signals to the brain, eliciting changes in energy intake and expenditure. The discovery of leptin and its receptors has now provided a molecular basis for this theory. Leptin functions as much more than an adipocyte-derived signal of lipid stores, however. Although suppression of food intake is an important centrally mediated effect of leptin, considerable evidence indicates that leptin also functions both directly and indirectly, via the brain, to orchestrate complex metabolic changes in a number of organs and tissues, altering nutrient flux to favor energy expenditure over energy storage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:17:09