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Titolo:
Prolactinomas in men: clinical and pathological characteristics
Autore:
Trouillas, J; Delgrange, E; Jouanneau, E; Maiter, D; Guigard, MP; Donckier, J; Perrin, G; Jan, M; Tourniaire, J;
Indirizzi:
Fac Med Lyon RTH Laennec, Unite INSERM U433, Lab Histol & Embryol Mol, F-69372 Lyon 08, France Fac Med Lyon RTH Laennec Lyon France 08 yol Mol, F-69372 Lyon 08, France Hop Mt Godinne, Dept Med Interne & Endocrinol, B-5530 Yvoir, Belgium Hop Mt Godinne Yvoir Belgium B-5530 & Endocrinol, B-5530 Yvoir, Belgium Hop Neurol, Serv Neurochirurg, F-69394 Lyon, France Hop Neurol Lyon France F-69394 , Serv Neurochirurg, F-69394 Lyon, France UCL St Luc, Dept Endocrinol & Nutr, B-1200 Brussels, Belgium UCL St Luc Brussels Belgium B-1200 inol & Nutr, B-1200 Brussels, Belgium Hop Bretonneau, Serv Neurochirurg, F-37044 Tours, France Hop Bretonneau Tours France F-37044 Neurochirurg, F-37044 Tours, France Hop Antiquaille, Clin Endocrinol, F-69321 Lyon 05, France Hop AntiquailleLyon France 05 Clin Endocrinol, F-69321 Lyon 05, France
Titolo Testata:
ANNALES D ENDOCRINOLOGIE
fascicolo: 3, volume: 61, anno: 2000,
pagine: 253 - 257
SICI:
0003-4266(200009)61:3<253:PIMCAP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
FRE
Soggetto:
PITUITARY-ADENOMAS; BROMOCRIPTINE; TUMORS; GROWTH; KI-67;
Keywords:
pituitary tumor; prolactin; Ki-67; dopamine agonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Trouillas, J Fac Med Lyon RTH Laennec, Unite INSERM U433, Lab Histol & Embryol Mol, F-69372 Lyon 08, France Fac Med Lyon RTH Laennec Lyon France 08372 Lyon 08, France
Citazione:
J. Trouillas et al., "Prolactinomas in men: clinical and pathological characteristics", ANN ENDOCR, 61(3), 2000, pp. 253-257

Abstract

Prolactinoma usually occurs a small intrasellar tumor in women or asa large tumor in men. To determine whether the predominance of macroprolactinomasin men is due to a delay in diagnosis as has been suggested, or whether there is a sex-related difference in growth rate we conducted a retrospectivestudy in 45 men and 51 women with prolactinomas. Preoperative prolactin level (PRL) was 2.789 +/- 573 ng/ml and mean tumor size was 26 +/- 2 mm. Prolactin levels and tumor size were significantly higher in women (292 +/- 74 ng/ml and 10 +/- 1 mm; p < 0.01). There was no correlation with age at diagnosis or duration of symptoms. Giant tumors were only observed in men (n = 8). Frequency of resistance to bromocriptine (30% vs 5%, p < 0.01) and invasive tumors (52% vs 27%, p < 0.001) were significantly higher in men than in women. Likewise, proliferation rate was higher for the prolactinomas in men (Ki-67: 2.6 +/- 1.1% positive nuclei vs 0.4 +/- 0.2%, p = 0.08; PCNA: 5.0 +/- 2.3% vs 3.7 +/- 1.1%). In conclusion, prolactinomas in men are more aggressive than in women. They grow rapidly, often invade the cavernous sinus and are resistant to bromocriptine; proliferation rates can be increased.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 04:40:53