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Titolo:
Tubular osteopontin expression in human glomerulonephritis and renal vasculitis
Autore:
Okada, H; Moriwaki, K; Konishi, K; Kobayashi, T; Sugahara, S; Nakamoto, H; Saruta, T; Suzuki, H;
Indirizzi:
Saitama Med Coll, Dept Nephrol, Moroyama, Saitama 3500495, Japan Saitama Med Coll Moroyama Saitama Japan 3500495 a, Saitama 3500495, Japan Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan Keio Univ Tokyo Japan io Univ, Sch Med, Dept Internal Med, Tokyo, Japan
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 3, volume: 36, anno: 2000,
pagine: 498 - 506
SICI:
0272-6386(200009)36:3<498:TOEIHG>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL CRESCENTIC GLOMERULONEPHRITIS; IGA NEPHROPATHY; EXPERIMENTAL HYDRONEPHROSIS; TUBULOINTERSTITIAL DISEASE; INTERSTITIAL FIBROSIS; RAT; PROTEIN; KIDNEY; NEPHROTOXICITY; DEPOSITION;
Keywords:
osteopontin (OPN); immunoglobulin A (IgA) nephropathy; lupus nephritis; myeloperoxidase-antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis (MMP); monocyte infiltration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, H Saitama Med Coll, Dept Nephrol, 38 Morohongo, Moroyama, Saitama 3500495, Japan Saitama Med Coll 38 Morohongo Moroyama Saitama Japan 3500495pan
Citazione:
H. Okada et al., "Tubular osteopontin expression in human glomerulonephritis and renal vasculitis", AM J KIDNEY, 36(3), 2000, pp. 498-506

Abstract

Tubulointerstitial change is a common histopathologic feature of acute andchronic glomerular diseases and is more closely correlated than glomerulardamage with renal function and subsequent outcome. Monocyte infiltration is presumed to be initiated by chemoattractants and has a pivotal role in tubulointerstitial changes. Osteopontin (OPN) is a candidate as such a chemoattractant and has been shown to recruit monocytes into the interstitium of animal models of renal diseases. In this study, we investigated OPN expression by immunostaining and its correlation with clinical and histopathologicparameters in patients with immunoglobulin A (IgA) nephropathy, diffuse proliferative lupus nephritis (DPLN), and myeloperoxidase-antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis (MMP), Twenty patients with IgA nephropathy, 12 patients with DPLN, and 14 patients with MMP were studied. OPN expression, which was constitutively observed on the apical membrane of distal tubules, was upregulated in the cytoplasm of proximaland distal tubular epithelium parallel to the degree of interstitial mononuclear cell infiltration in patients with IgA nephropathy, as well as thosewith DPLN. CD68(+) monocyte infiltration significantly correlated with thedegree of OPN expression in the tubular epithelium. Conversely, there was no apparent induction of OPN in the proximal and distal tubular epithelium of patients with MMP despite remarkable monocyte infiltration. In conclusion, these data suggest that inducible expression of OPN in the tubular epithelium seems to be associated with interstitial monocyte infiltration and subsequent tubulointerstitial changes in some forms of human renal diseases. (C) 2000 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:37:06