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Titolo:
Intercellular-adhesion-molecule-1 as diagnostic serum marker for chorioamnionitis, preeclampsia and HELLP-syndrome
Autore:
Steinborn, A; Sohn, C; Scharf, A; Geka, F; Haas, S; Kaufmann, M;
Indirizzi:
Univ Frankfurt, Frauenklin, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 lin, D-60590 Frankfurt, Germany
Titolo Testata:
ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE
fascicolo: 4, volume: 204, anno: 2000,
pagine: 140 - 145
SICI:
0948-2393(200007/08)204:4<140:IADSMF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
GER
Soggetto:
CELL-ADHESION MOLECULES; C-REACTIVE PROTEIN; PRETERM LABOR; HISTOLOGIC CHORIOAMNIONITIS; INTRAAMNIOTIC INFECTION; INFLAMMATORY MEDIATORS; INTRAUTERINE INFECTION; PREMATURE RUPTURE; CYTOKINE RELEASE; INTERLEUKIN-6;
Keywords:
preterm labor; chorioamnionitis; preeclampsia; HELLP-syndrome; adhesion molecules;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Steinborn, A Univ Frankfurt, Frauenklin, Theodor Stern Kai 7, D-60590 Frankfurt, Germany Univ Frankfurt Theodor Stern Kai 7 Frankfurt Germany D-60590
Citazione:
A. Steinborn et al., "Intercellular-adhesion-molecule-1 as diagnostic serum marker for chorioamnionitis, preeclampsia and HELLP-syndrome", Z GEBU NEON, 204(4), 2000, pp. 140-145

Abstract

Introduction: Chorioamnionitis and pregnancy-induced hypertension both areextremely feared complications of human pregnancy. Activation or disturbance of normal endothelial cell function may be involved in the pathogenesis of both kinds of disease. The aim of our study was to compare the diagnostic value of soluble intercellular-adhesion-molecule-1 (ICAM-1) with that of C-reactive protein (CRP) and white blood cell count for the detection of chorioamnionitis in patients with preterm labor. In addition, we examined if concentrations of ICAM-1 were also increased in case of preeclampsia or HELLP-syndrome. Materials and Methods: ICAM-1, CRP and leucocyte count were estimated in 50 cases of normal term delivery, 97 cases of uncontrollable preterm labor, 16 cases of preeclampsia and 9 cases of HELLP-syndrome before delivery. Results: From 97 women delivering preterm, chorioamnionitis was histologically confirmed for 48 women. Maternal serum levels of ICAM-1 (p<0.001), CRP(p<0.001) and leucocyte count (p<0.02) were significantly higher in the group of preterm delivering patients (<37 weeks gestation) with histologically confirmed chorioamnionitis in comparison to preterm delivering patients in the absence of chorioamnionitis. In the group of patients delivering preterm (<37 weeks gestation) because of preeclampsia or HELLP-syndrome, ICAM-1(p<0.001), as well as CRP (p<0.006) concentrations were also significantlyincreased in comparison to patients delivering preterm in the absence of chorioamnionitis. Conclusions: Elevated levels of ICAM-1 in the serum of pregnant women may be considered as an important risk factor for the development of complications in pregnancy associated with inflammatory induced changes of maternal endothelial cell functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:32:16