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Titolo:
Options for tissue engineering to address challenges of the aging skeleton
Autore:
Hollinger, JO; Winn, S; Bonadio, J;
Indirizzi:
Carnegie Mellon Univ, Bone Tissue Engn Ctr, Dept Biol Sci, Pittsburgh, PA 15213 USA Carnegie Mellon Univ Pittsburgh PA USA 15213 ci, Pittsburgh, PA 15213 USA Carnegie Mellon Univ, Bone Tissue Engn Ctr, Dept Biomed Engn, Pittsburgh, PA 15213 USA Carnegie Mellon Univ Pittsburgh PA USA 15213 gn, Pittsburgh, PA 15213 USA Oregon Hlth Sci Univ, Dept Cell & Mol Biol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 l Biol, Portland, OR 97201 USA Select Genet Inc, San Diego, CA USA Select Genet Inc San Diego CA USASelect Genet Inc, San Diego, CA USA
Titolo Testata:
TISSUE ENGINEERING
fascicolo: 4, volume: 6, anno: 2000,
pagine: 341 - 350
SICI:
1076-3279(200008)6:4<341:OFTETA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE MORPHOGENETIC PROTEIN-2; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR-BETA; OVARIECTOMIZED RATS; GENE-THERAPY; PARATHYROID-HORMONE; TRABECULAR BONE; CORTICAL BONE; PLASMID DNA; AGED RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Hollinger, JO Carnegie Mellon Univ, Bone Tissue Engn Ctr, Dept Biol Sci, 218 Smith Hall,5000 Forbes Ave, Pittsburgh, PA 15213 USA Carnegie Mellon Univ 218 Smith Hall,5000 Forbes Ave Pittsburgh PA USA 15213
Citazione:
J.O. Hollinger et al., "Options for tissue engineering to address challenges of the aging skeleton", TISSUE ENG, 6(4), 2000, pp. 341-350

Abstract

There will be more than 52 million Americans over the age of 65 by the year 2020 (U.S. Census Bureau). Regenerating form and function to bone defectsin an elderly, osteoporotic population of this magnitude will be a daunting challenge. Tissue engineering options must be considered to answer this challenge. Options can include gene transfer technology, stem cell therapy, and recombinant signaling molecules. An additional component will be a carrier that localizes, protects, predictably releases cues and cells, as well as establishes an environment for restoring osseous form and function. The purposes of this article are to present an overview of the bone regenerating decrement affecting osteoporotic, elderly patients and to highlight some tissue engineering options that could offset this decrement.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:54:28