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Titolo:
Quality of life in schizophrenia: A comparison of instruments
Autore:
Cramer, JA; Rosenheck, R; Xu, WC; Thomas, J; Henderson, W; Charney, DS;
Indirizzi:
VA Connecticut Healthcare Syst G7E, W Haven, CT 06516 USA VA Connecticut Healthcare Syst G7E W Haven CT USA 06516 ven, CT 06516 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA
Titolo Testata:
SCHIZOPHRENIA BULLETIN
fascicolo: 3, volume: 26, anno: 2000,
pagine: 659 - 666
SICI:
0586-7614(2000)26:3<659:QOLISA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
OF-LIFE; MENTAL-ILLNESS; SCALE; CLOZAPINE;
Keywords:
schizophrenia; quality of life; clinical trial; functional status; symptoms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Cramer, JA VA Connecticut Healthcare Syst G7E, 950 Campbell Ave, W Haven, CT 06516 USA VA Connecticut Healthcare Syst G7E 950 Campbell Ave W Haven CTUSA 06516
Citazione:
J.A. Cramer et al., "Quality of life in schizophrenia: A comparison of instruments", SCHIZO BULL, 26(3), 2000, pp. 659-666

Abstract

Health-related quality of life in schizophrenia can be assessed by direct patient response or by a rating based on a structured interview. This studycompares both types of instruments using a series of five standards: (1) sensitivity to change over time, (2) sensitivity to treatment effect, (3) correlation with symptom severity, (4) correlation with global clinical ratings, and (5) correlation with other measures of health-related quality of life. Four hundred and twenty-three inpatients with schizophrenia participating in a clinical trial comparing clozapine and haloperidol (VA Cooperative Study in Health Services #17) were evaluated using multiple measures of health-related quality of life (Lehman Quality of Life Interview; Heinrichs-Carpenter-Hanlon Quality of Life Scale; Strauss-Carpenter Level of Function scale, and clinical response. ) The Quality of Life Interview showed less sensitivity to change and treatment effect, as well as lower correlations withail other measures than the Quality of Life Scale and the Level of Function scale. The latter scales showed high sensitivity to both change and treatment effect, and moderate-high correlations with other measures and with each other. The Quality of Life Scale and the Level of Function scale rater assessments appeared to be substantially more sensitive to subtle change andtreatment effects than the patient-reported Quality of Life Interview for clinical trials. Health-related quality of life in schizophrenia Is a more heterogeneous concept than previously appreciated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:50:14