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Titolo:
Fibromyalgia - symptom or diagnosis: A definition of the position
Autore:
Pongratz, DE; Sievers, M;
Indirizzi:
Univ Munich, Friedrich Baur Inst, DE-80336 Munich, Germany Univ Munich Munich Germany DE-80336 Baur Inst, DE-80336 Munich, Germany
Titolo Testata:
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
, volume: 29, anno: 2000, supplemento:, 113
pagine: 3 - 7
SICI:
0300-9742(2000)29:<3:F-SODA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE BIOPSY; SUBSTANCE-P; PERTURBATIONS;
Keywords:
fibromyalgia; myofascial pain syndrome; metabolic myopathies; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Pongratz, DE Univ Munich, Friedrich Baur Inst, Ziemssenstr 1, DE-80336 Munich, Germany Univ Munich Ziemssenstr 1 Munich Germany DE-80336 h, Germany
Citazione:
D.E. Pongratz e M. Sievers, "Fibromyalgia - symptom or diagnosis: A definition of the position", SC J RHEUM, 29, 2000, pp. 3-7

Abstract

According to the American College of Rheumatology the diagnosis of fibromyalgia is based on criteria for the classification of fibromyalgia consisting entirely of clinical signs and symptoms. For diagnostic reasons autonomicdisturbances and mental features have to be considered. The distinction between fibromyalgia (tender points) and myofascial pain syndrome (trigger points) is essential. Internal and neurological disorders as a primary cause of fibromyalgia have to be excluded. The etiology and pathogenesis of fibromyalgia still remain uncertain. The myopathological patterns in fibromyalgia are non-specific: type II fiber atrophy, an increase of lipid droplets, aslight proliferation of mitochondria, and a slightly elevated incidence ofragged red fibers. Initial reports on some allelic abnormalities in the serotonin system seem to highlight the important role of serotonin already presumed earlier. Significantly high levels of substance P in the cerebrospinal fluid of FM patients additionally support the impact of these neurotransmitters on both nociceptive and antinociceptive mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:32:08