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Titolo:
Diagnostic problems of MRI in studying the effect of G-CSF therapy in bonemarrow of patients with malignoma
Autore:
Layer, G; Sander, W; Traber, F; Block, W; Ko, Y; Ziske, CG; Konig, R; Vahlensieck, M; Schild, HH;
Indirizzi:
Univ Bonn, Radiol Klin, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 Bonn, Radiol Klin, D-53105 Bonn, Germany Univ Klin Bonn, Med Poliklin, Bonn, Germany Univ Klin Bonn Bonn GermanyUniv Klin Bonn, Med Poliklin, Bonn, Germany Univ Bonn, Med Klin, D-5300 Bonn, Germany Univ Bonn Bonn Germany D-5300Univ Bonn, Med Klin, D-5300 Bonn, Germany
Titolo Testata:
RADIOLOGE
fascicolo: 8, volume: 40, anno: 2000,
pagine: 710 - 715
SICI:
0033-832X(200008)40:8<710:DPOMIS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
GER
Soggetto:
MULTIPLE-MYELOMA; GROWTH-FACTORS; CHEMOTHERAPY; METASTASES;
Keywords:
magnetic resonance (MR); MR-tomography; MR-spectroscopy; relaxometry; fat-/water-analysis; bone marrow metastasis; bone marrow infiltration; granulocyte colony stimulating factor (G-CSF);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Layer, G Univ Bonn, Radiol Klin, Sigmund Freud Str 25, D-53105 Bonn, Germany Univ Bonn Sigmund Freud Str 25 Bonn Germany D-53105 onn, Germany
Citazione:
G. Layer et al., "Diagnostic problems of MRI in studying the effect of G-CSF therapy in bonemarrow of patients with malignoma", RADIOLOGE, 40(8), 2000, pp. 710-715

Abstract

Aim. To study the effect of G-CSF therapy directly by MRI and H-1 MRS in the lumbar and femoral bone marrow and differentiate between malignant bone marrow infiltration (MBMI) and reconversion of red marrow. Methods. Thirteen patients could be examined twice, before and during G-CSF medicatio and another six only during treatment. T1 weighted spin-echo and opposed-phase gradient-echo images as well as the spectroscopic data (T2 values, water content) were analysed. Results. After G-CSF a pathologic bone marrow signal intensity was seen in8/13 (lumbar) and 11/13(femoral) patients respectively. The majority of the signal alterations were diffuse (6 and 8),the minority focal (2 and 3). If a patient was successfully stimulated, a significant increase in water content occured (21% lumbar, 34% femoral). T2 values did not change significantly, nor did they correlate with the stimulation success. Conclusions. MR tomography and -spectroscopy are suitable to detect lumbarand femoral bone marrow stimulation by G-CSF quantitatively and qualitatively. The changes may simulate MBMI. The adequate judgement of G-CSF treatedbone marrow without pretherapeutic images is not possible.

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Documento generato il 30/03/20 alle ore 10:14:40