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Titolo:
Substituting proxy ratings for patient ratings in cancer clinical trials: An analysis based on a Southwest Oncology Group trial in patients with brain metastases
Autore:
Moinpour, CM; Lyons, B; Schmidt, SP; Chansky, K; Patchell, RA;
Indirizzi:
Janssen Res Fdn, Titusville, NJ USA Janssen Res Fdn Titusville NJ USAJanssen Res Fdn, Titusville, NJ USA Freeman Hlth Syst, Joplin, MO USA Freeman Hlth Syst Joplin MO USAFreeman Hlth Syst, Joplin, MO USA Univ Kentucky, Med Ctr, Lexington, KY USA Univ Kentucky Lexington KY USAUniv Kentucky, Med Ctr, Lexington, KY USA SW Oncol Grp, Ctr Stat, Seattle, WA USA SW Oncol Grp Seattle WA USASW Oncol Grp, Ctr Stat, Seattle, WA USA
Titolo Testata:
QUALITY OF LIFE RESEARCH
fascicolo: 2, volume: 9, anno: 2000,
pagine: 219 - 231
SICI:
0962-9343(200003)9:2<219:SPRFPR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUALITY-OF-LIFE; END-POINTS; SIGNIFICANT OTHERS; HEALTH-STATUS; AGREEMENT; SURROGATE; CONCORDANCE;
Keywords:
proxy measures; quality of life; surrogacy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Moinpour, CM SW Oncol Grp, Operat Off, 14980 Omicron Dr, San Antonio, TX 78245 USA SW Oncol Grp 14980 Omicron Dr San Antonio TX USA 78245 45 USA
Citazione:
C.M. Moinpour et al., "Substituting proxy ratings for patient ratings in cancer clinical trials: An analysis based on a Southwest Oncology Group trial in patients with brain metastases", QUAL LIFE R, 9(2), 2000, pp. 219-231

Abstract

In studies of the effect of cancer treatment in the advanced disease setting, researchers have attempted to avoid missing data for quality of life (QOL) assessments by either substituting proxy for patient assessments from the outset or by interspersing proxy measures when patients are unable to respond. Although poor agreement between patient and proxy assessments has been amply demonstrated in the literature, interest in using proxy measures persists. Completion of the Spitzer QL-Index by a small sample of patients with brain metastases and family member proxies provided data for evaluatingthe ability to substitute proxy for patient QOL assessments. These data cannot address treatment efficacy due to the modest sample size. Rather, the analyses serve to alert researchers to the important distinction (in a clinical trial setting) between agreement and the use of the proxy as a surrogate. We present several methods for evaluating the accuracy of proxy measures and for identifying other sources of error and bias that may vary with time or with treatment arm. Lin's concordance correlation coefficient suggests that proxies are generally a poor substitute for capturing a patient's perspective of his/her QOL. A longitudinal analysis suggests that the use of proxy rather than patient responses could lead to different conclusions concerning radiation therapy's effect on QOL.

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Documento generato il 04/04/20 alle ore 14:27:13