Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Endothelium-independent and -dependent vasodilation in alkalotic and acidotic piglet lungs
Autore:
Balasubramanyan, N; Halla, TR; Ghanayem, NS; Gordon, JB;
Indirizzi:
Med Coll Wisconsin, Dept Pediat, Crit Care Sect, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 e Sect, Milwaukee, WI 53226 USA Vet Adm Med Ctr, Milwaukee, WI 53295 USA Vet Adm Med Ctr Milwaukee WI USA53295 m Med Ctr, Milwaukee, WI 53295 USA
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 3, volume: 30, anno: 2000,
pagine: 241 - 248
SICI:
8755-6863(200009)30:3<241:EA-VIA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERSISTENT PULMONARY-HYPERTENSION; INHALED NITRIC-OXIDE; SMOOTH-MUSCLE CELLS; INTRACELLULAR PH; RESPIRATORY ALKALOSIS; VASCULAR-RESISTANCE; VASOCONSTRICTION; NEWBORN; RESPONSES; HYPOXIA;
Keywords:
nitric oxide; acetylcholine; hypoxia; pulmonary circulation; pulmonary hypertension; permissive hypercapnia; alkalosis; acidosis; animal models; papaverine; acetylcholine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Gordon, JB Childrens Hosp Wisconsin, Crit Care Sect, MS 681,POB 1997, Milwaukee, WI 53201 USA Childrens Hosp Wisconsin MS 681,POB 1997 Milwaukee WI USA 53201
Citazione:
N. Balasubramanyan et al., "Endothelium-independent and -dependent vasodilation in alkalotic and acidotic piglet lungs", PEDIAT PULM, 30(3), 2000, pp. 241-248

Abstract

Although significant pulmonary hypertension can occur in patients treated with either hypocapnic alkalosis or "permissive" hypercapnic acidosis, the effects of sustained alkalosis or acidosis on subsequent vasodilator responses have not been established. This study measured the effects of 60-100 min of sustained alkalosis or acidosis on endothelium-independent and -dependent vasodilation with inhaled nitric oxide (iNO) and acetylcholine (ACh) inisolated lungs from 1-week-old piglets. After stabilization, lungs were divided into control (pH 7.40, PaCO2 40 torr, n = 5), alkalotic (pH 7.60, PaCO2 25 torr, n = 6), or acidotic (pH 7.25, PaCO2 65 torr, n = 5) groups and ventilated with 21% O-2 for 40 min. Acute hypoxic pulmonary vasoconstriction (HPV) was then induced with 4-6% O-2. After a stable presser response hadoccurred (approximate to 20 min). pulmonary artery dose-response relationships to increasing concentrations of iNO were measured. The iNO was then stopped and after a stable hypoxic pressure had again been reestablished (approximate to 20 min), dose-responses to increasing concentrations of ACh were measured. Hypoxic pulmonary vascular resistance (PVR) was similar in all groups. Pulmonary artery pressure dose-response relationships to iNO and ACh were blunted in the alkalosis group, suggesting that both endothelium-independent and -dependent vasodilation were reduced during sustained hypocapnic alkalosis. In contrast, sustained acidosis did not alter subsequent vasodilator responses. Future studies must elucidate the mechanisms underlying blunted pulmonary vasodilation during sustained alkalosis and examine the consequences of sustained alkalosis therapy on subsequent vasodilator responses in clinical practice. Pediatr Pulmonol. 2000; 30:241-248. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:31:13