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Titolo:
Immunoblot analysis of IgA antibodies to Naegleria fowleri in human salivaand serum
Autore:
Rivera-Aguilar, V; Hernandez-Martinez, D; Rojas-Hernandez, S; Oliver-Aguillon, G; Tsutsumi, V; Herrera-Gonzalez, N; Campos-Rodriguez, R;
Indirizzi:
Natl Polytech Inst, Sch Med, Dept Biochem, Mexico City 11340, DF, Mexico Natl Polytech Inst Mexico City DF Mexico 11340 ico City 11340, DF, Mexico UNAM, ENEP Iztacala, Project Conservat & Improvement Environm, Tlalnepantla 54090, Edo De Mexico, Mexico UNAM Tlalnepantla Edo De Mexico Mexico 54090 54090, Edo De Mexico, Mexico CINVESTAV, Dept Expt Pathol, Mexico City 07360, DF, Mexico CINVESTAV Mexico City DF Mexico 07360 thol, Mexico City 07360, DF, Mexico
Titolo Testata:
PARASITOLOGY RESEARCH
fascicolo: 9, volume: 86, anno: 2000,
pagine: 775 - 780
SICI:
0932-0113(200009)86:9<775:IAOIAT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Campos-Rodriguez, R Natl Polytech Inst, Sch Med, Dept Biochem, Mexico City11340, DF, Mexico Natl Polytech Inst Mexico City DF Mexico 11340 Mexico
Citazione:
V. Rivera-Aguilar et al., "Immunoblot analysis of IgA antibodies to Naegleria fowleri in human salivaand serum", PARASIT RES, 86(9), 2000, pp. 775-780

Abstract

The objective of this study was to evaluate the secretory IgA (SIgA) antibody response to Naegleria fowleri (Nf) in individuals living in a parasite endemic area. Saliva and serum samples were obtained from both healthy subjects and patients suffering from a respiratory illness (chronic bronchitis or rhinitis) and were analyzed by immunoblot assay. SIgA from the patients'samples recognized more intensely a greater number of Nf proteins than didSIgA from the healthy control group. The proteins more frequently recognized were those with a molecular weight of 171, 107, 102, 62, 50, 46, and 10 kDa. Some IgA antibodies recognized proteins from Nf and Entamoeba histolytica (Eh) of similar molecular weight. These results suggest that some of those antibodies could have been elicited by a previous intestinal infection with Eh. Through the common mucosal immune system the IgA B-cells activatedby Eh antigens can be disseminated to all the mucosae, including the nasalmucosa. SIgA antibodies recognizing Nf proteins, induced either by specific immunization or by cross-reaction, could participate in the resistance tothe infection, probably by inhibiting the adherence of Nf trophozoites to the nasal mucosa.

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Documento generato il 27/01/20 alle ore 01:22:31