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Titolo:
A CBF-based event-related brain activation paradigm: Characterization of impulse-response function and comparison to BOLD
Autore:
Yang, YH; Engelien, W; Pan, H; Xu, S; Silbersweig, DA; Stern, E;
Indirizzi:
Cornell Univ, Weill Med Coll, Dept Psychiat, Funct Neuroimaging Lab, New York, NY 10021 USA Cornell Univ New York NY USA 10021 uroimaging Lab, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA
Titolo Testata:
NEUROIMAGE
fascicolo: 3, volume: 12, anno: 2000,
pagine: 287 - 297
SICI:
1053-8119(200009)12:3<287:ACEBAP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; SENSORY STIMULATION; FMRI; PERFUSION; INVERSION; MULTISLICE; CONTRAST; OXYGENATION; FREQUENCY; ARTIFACTS;
Keywords:
event-related functional MRI; brain perfusion imaging; cerebral blood flow; brain hemodynamic-neuronal response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, YH Cornell Univ, Weill Med Coll, Dept Psychiat, Funct Neuroimaging Lab, New York, NY 10021 USA Cornell Univ New York NY USA 10021 g Lab, New York, NY 10021 USA
Citazione:
Y.H. Yang et al., "A CBF-based event-related brain activation paradigm: Characterization of impulse-response function and comparison to BOLD", NEUROIMAGE, 12(3), 2000, pp. 287-297

Abstract

A perfusion-based event-related functional MRI method for the study of brain activation is presented. In this method, cerebral blood flow (CBF) was measured using a recently developed multislice arterial spin-labeling (ASL) perfusion imaging method with rapid spiral scanning. Temporal resolution ofthe perfusion measurement was substantially improved by employing intertrial subtraction and stimulus-shifting schemes. Perfusion and blood oxygenation level-dependent (BOLD) signals were obtained simultaneously by subtracting or adding the control and labeled images, respectively, in the same datasets. The impulse response function (IRF) of perfusion during brain activation was characterized for multiple stimulus durations and compared to the simultaneously acquired BOLD response. The CBF response curve preceded the BOLD curve by 0.21 s in the rising phase and 0.64 s in the falling phase. Linear additivity of the CBF and BOLD responses was assessed with rapidly repeated stimulations within single trials, and departure from linearity was found in both responses, characterized as attenuated amplitude and delayed rising time. Event-related visual and sensorimotor activation experiments were successfully performed with the new perfusion technique, (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:11:57