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Titolo:
Overexpression of GluR6 in rat hippocampus produces seizures and spontaneous nonsynaptic bursting in vitro
Autore:
Telfeian, AE; Federoff, HJ; Leone, P; During, MJ; Williamson, A;
Indirizzi:
Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT 06520 USA Yale Univ NewHaven CT USA 06520 Dept Neurosurg, New Haven, CT 06520 USA
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 4, volume: 7, anno: 2000,
pagine: 362 - 374
SICI:
0969-9961(200008)7:4<362:OOGIRH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; CELL AXON REORGANIZATION; KAINATE-TREATED RATS; PYRAMIDAL NEURONS; FIRING PATTERNS; NEOCORTICAL NEURONS; CA2+ PERMEABILITY; DENTATE GYRUS; GRANULE CELLS; SLICES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Williamson, A Yale Univ, Sch Med, Dept Neurosurg, 333 Cedar St,POB 208039,New Haven, CT06520 USA Yale Univ 333 Cedar St,POB 208039 New Haven CT USA 06520 USA
Citazione:
A.E. Telfeian et al., "Overexpression of GluR6 in rat hippocampus produces seizures and spontaneous nonsynaptic bursting in vitro", NEUROBIOL D, 7(4), 2000, pp. 362-374

Abstract

We hypothesized that overexpression of specific glutamate receptors withinthe hippocampus would induce seizures and the associated cellular changes seen in temporal lobe epilepsy (TLE). The GluR6 kainate receptor was overexpressed by injecting rat hippocampi with HSVGluR6, a viral vector transducing fully edited GluR6, These animals experienced limbic seizures approximately 4 h following the injection, Control animals injected with HSVlac, a vector expressing beta-galactosidase, did not have seizures. Recordings from hippocampal CA1 pyramidal cells were performed 12 to 48 h and 1 week to 1 month postinjection. We observed nonsynaptic Na C-mediated bursting in 77.5%of cells 12 to 48 h following injection of HSVGluR6 but not HSVlac, The synaptic responses were normal in both groups. However, the physiological properties of cells from HSVGluR6-injected hippocampi changed over time. Two weeks following HSVGluR6 injection, synaptic bursts could be evoked, but intrinsic bursting became rare. These changes persisted for at least 1 month. We postulate that this transition from intrinsic to synaptic hyperexcitability may be important in the development of TLE. (C) 2000 Academic Press.

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Documento generato il 29/03/20 alle ore 08:40:11