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Titolo:
Shunting is a translation strategy used by plant pararetroviruses (Caulimoviridae)
Autore:
Hohn, T; Corsten, S; Dominguez, D; Futterer, J; Kirk, D; Hemmings-Mieszczak, M; Pooggin, M; Scharer-Hernandez, N; Ryabova, L;
Indirizzi:
Friedrich Miescher Inst, CH-4002 Basel, Switzerland Friedrich Miescher Inst Basel Switzerland CH-4002 002 Basel, Switzerland
Titolo Testata:
MICRON
fascicolo: 1, volume: 32, anno: 2001,
pagine: 51 - 57
SICI:
0968-4328(200101)32:1<51:SIATSU>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAULIFLOWER MOSAIC-VIRUS; OPEN READING FRAME; NONLINEAR RIBOSOME MIGRATION; STABLE HAIRPIN; MESSENGER-RNA; SECONDARY STRUCTURE; 35S RNA; INITIATION; LEADER; SEQUENCE;
Keywords:
Shine-Dalgarno sequences; shunting; eukaryotic ribosomes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Hohn, T Friedrich Miescher Inst, POB 2543, CH-4002 Basel, Switzerland Friedrich Miescher Inst POB 2543 Basel Switzerland CH-4002 erland
Citazione:
T. Hohn et al., "Shunting is a translation strategy used by plant pararetroviruses (Caulimoviridae)", MICRON, 32(1), 2001, pp. 51-57

Abstract

In eukaryotes standard initiation of translation involved 40S ribosome scanning to bridge the distance from the cap to the initiation codon. Recentlydeviations from that rule had been described, including "internal initiation", "poly-A dependent translation", and "ribosome shunting". In ribosome shunting, ribosomes start scanning at the cap but large portions of the leader are skipped. Thereby the secondary structure of the shunted region is preserved. Scanning in plant caulimoviruses involve a small open reading frame properly spaced in front of a strong stem structure, and, in order to function, the small open reading frome has to be translated and the peptide released. This arrangement can be mimicked by artificial small open reading frames and stem structures. Shunting with viral and synthetic leaders occursnot only in plant-, but also in mammalian and yeast systems. Thus it responds to an intrinsic property of the eukaryotic translational machinery and probably acts in many cases where coding regions are preceded by complex leaders. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 23:49:02