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Titolo:
Cyclooxygenase isoenzymes and newer therapeutic potential for selective COX-2 inhibitors
Autore:
Kulkarni, SK; Jain, NK; Singh, A;
Indirizzi:
Panjab Univ, Univ Inst Pharmaceut Sci, Div Pharmacol, Chandigarh 160014, India Panjab Univ Chandigarh India 160014 Pharmacol, Chandigarh 160014, India Panacea Biotec Ltd, Res & Dev Div, Punjab, India Panacea Biotec Ltd Punjab India iotec Ltd, Res & Dev Div, Punjab, India
Titolo Testata:
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
fascicolo: 5, volume: 22, anno: 2000,
pagine: 291 - 298
SICI:
0379-0355(200006)22:5<291:CIANTP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PROSTAGLANDIN-G/H SYNTHASE; ENDOPEROXIDE-H SYNTHASE-1; MESSENGER-RNA; INDUCIBLE CYCLOOXYGENASE; ALZHEIMERS-DISEASE; RAT-BRAIN; GASTROINTESTINAL TOXICITY; COLON CARCINOGENESIS; ENDOTHELIAL-CELLS;
Keywords:
cyclooxygenase enzyme; nonsteroidal antiinflammatory drugs; selective COX-2 inhibitors; newer therapeutic potentials;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Kulkarni, SK Panjab Univ, Univ Inst Pharmaceut Sci, Div Pharmacol, Chandigarh 160014, India Panjab Univ Chandigarh India 160014 handigarh 160014, India
Citazione:
S.K. Kulkarni et al., "Cyclooxygenase isoenzymes and newer therapeutic potential for selective COX-2 inhibitors", METH FIND E, 22(5), 2000, pp. 291-298

Abstract

Cyclooxygenase (COX), also known as prostaglandin G/H synthase, is a membrane-bound enzyme responsible for the oxidation of arachidonic acid to prostaglandins that was first identified over 20 years ago. In the past decade, however,more progress has been made in understanding the role of cyclooxygenase enzymes in various pathophysiological conditions. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. COX-1 enzyme is constitutively expressed and regulates a number of housekeeping functions such as vascular hemostasis and gastroprotection, whereas COX-2 isinducible (i.e. sites of inflammation) by number of mediators such as growth factors, cytokines and endotoxins. Nonsteroidal antiinflammatory drugs (NSAIDs) produce their therapeutic effects through inhibition of COX, the enzyme that makes prostaglandins. Nonselective inhibition of COX isoenzyme leads to not only beneficia therapeutic effects but also a number of detrimental effects. Beneficial effects are due to inhibition of COX-2 and detrimental effects are due to inhibition of physiological COX-1. The present review discusses the biology as well as the role of these COX isoenzyme sin various pathophysiological conditions. (C) 2000 Prous Science. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:08:30