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Titolo:
Efficacy of fenfluramine and dexfenfluramine in the treatment of obesity: A meta-analysis
Autore:
Carvajal, A; del Pozo, JG; de Diego, IM; de Castro, AMR; Velasco, A;
Indirizzi:
Univ Valladolid, Inst Farmacoepidemiol, Valladolid, Spain Univ ValladolidValladolid Spain st Farmacoepidemiol, Valladolid, Spain
Titolo Testata:
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
fascicolo: 5, volume: 22, anno: 2000,
pagine: 285 - 290
SICI:
0379-0355(200006)22:5<285:EOFADI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR RISK-FACTORS; APPETITE-SUPPRESSANT DRUGS; BLIND CLINICAL-TRIAL; BODY-WEIGHT; BLOOD-PRESSURE; PLACEBO; PHENTERMINE; THERAPY; REGURGITATION; THERMOGENESIS;
Keywords:
weight loss; fenfluramine; dexfenfluramine; clinical trial; meta-analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Carvajal, A Fac Med, Inst Farmacoepidemiol, Avd Ramon & Cajal 7, Valladolid, Spain Fac Med Avd Ramon & Cajal 7 Valladolid Spain lladolid, Spain
Citazione:
A. Carvajal et al., "Efficacy of fenfluramine and dexfenfluramine in the treatment of obesity: A meta-analysis", METH FIND E, 22(5), 2000, pp. 285-290

Abstract

A meta-analysis was conducted to estimate the difference of weight loss among patients treated with placebo and with fenfluramine or dexfenfluramine after 1, 2, 3, 6, and 12 months of treatment. Placebo-controlled double-blind, randomized clinical trials, whose results were presented as weight lossby the placebo group and the drug-treated patient group, were selected forthe analysis. For the pooled estimations, the method of the weighted meansby the inverse of the the variance was used. The association between the difference of means and several predictive variables was studied by means ofweighted linear regression. Patients treated with fenfluramine or dexfenfluramine achieved a higher weight loss than those receiving placebo in ail the periods studied. The greatest efficacy was observed after 3 months of treatment. Beyond this rime, there is a decline in the effectiveness. Based on the efficacy data, treatments longer than 3 months would not be justified. (C) 2000 Prous Science. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:42:36