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Titolo:
Cloning and chromosomal assignment of the porcine interleukin-2 receptor alpha (IL-2R alpha) gene
Autore:
Kokuho, T; Hiraiwa, H; Yasue, H; Watanabe, S; Yokomizo, Y; Inumaru, S;
Indirizzi:
Natl Inst Anim Hlth, Dept Biol Prod, Tsukuba, Ibaraki 3050856, Japan Natl Inst Anim Hlth Tsukuba Ibaraki Japan 3050856 Ibaraki 3050856, Japan STAFF Inst, Anim Genome Program Team, Tsukuba, Ibaraki 3050854, Japan STAFF Inst Tsukuba Ibaraki Japan 3050854 Tsukuba, Ibaraki 3050854, Japan Natl Inst Anim Ind, Anim Genome Res Grp, Ibaraki, Osaka 3050901, Japan Natl Inst Anim Ind Ibaraki Osaka Japan 3050901 raki, Osaka 3050901, Japan
Titolo Testata:
JOURNAL OF VETERINARY MEDICAL SCIENCE
fascicolo: 8, volume: 62, anno: 2000,
pagine: 841 - 847
SICI:
0916-7250(200008)62:8<841:CACAOT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN IL-2 RECEPTOR; TUMOR-NECROSIS-FACTOR; GAMMA-CHAIN; EXPRESSION; TRANSCRIPTION; CELLS; ACTIVATION; ELEMENTS; BINDING; COMPLEX;
Keywords:
genome mapping; interleukin(IL)-2 receptor; swine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Yokomizo, Y Natl Inst Anim Hlth, Dept Bacteriol & Parasitol, 3-1-1 Kannondai, Tsukuba,Ibaraki 3050856, Japan Natl Inst Anim Hlth 3-1-1 Kannondai Tsukuba Ibaraki Japan 3050856
Citazione:
T. Kokuho et al., "Cloning and chromosomal assignment of the porcine interleukin-2 receptor alpha (IL-2R alpha) gene", J VET MED S, 62(8), 2000, pp. 841-847

Abstract

Porcine genomic DNA encoding a 55 kDa subunit of interleukin-2 receptor (IL-2R), which is termed alpha chain (IL-2R alpha), was cloned by repeated plaque hybridization using IL-2R alpha cDNA as a probe. Two different lambda phage clones, one of which encoded exon 1 and the 5'-upstream flanking region of IL-2R alpha gene and another encoded the sequence from exon 2 to exon8, were isolated. By analysis of the 5'-upstream region of the gene, putative binding motifs for transcription factors such as GATA family proteins, Ikaros, NF-kappa B, NF-IL2R alpha and SRF, were Found as described in human, murine and bovine genes. Two additional motifs for STAT4 binding were also found in this region. Moreover, using the FISH technique, we assigned theporcine IL-2R alpha locus to the distal end of the long arm of chromosome 10 (10q6-qter) where the vimentin gene had been assigned nearby.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:24:08