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Titolo:
Axonal damage revealed by accumulation of beta-amyloid precursor protein in HTLV-I-associated myelopathy
Autore:
Umehara, F; Abe, M; Koreeda, Y; Izumo, S; Osame, M;
Indirizzi:
Kagoshima Univ, Sch Med, Dept Internal Med 3, Kagoshima 890, Japan Kagoshima Univ Kagoshima Japan 890 Internal Med 3, Kagoshima 890, Japan Kagoshima Univ, Chron Viral Dis Res Ctr, Div Mol Pathol, Kagoshima 890, Japan Kagoshima Univ Kagoshima Japan 890 Div Mol Pathol, Kagoshima 890, Japan
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 2, volume: 176, anno: 2000,
pagine: 95 - 101
SICI:
0022-510X(20000615)176:2<95:ADRBAO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL-CORD LESIONS; VIRUS TYPE-I; TROPICAL SPASTIC PARAPARESIS; MULTIPLE-SCLEROSIS LESIONS; T-LYMPHOCYTES; HEAD-INJURY; HUMAN BRAIN; EXPRESSION; APP; IMMUNOREACTIVITY;
Keywords:
HTLV-I; HTLV-I-associated myelopathy; axonal damage; beta-amyloid precursor protein; axonal flow; HAM/TSP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Umehara, F Kagoshima Univ, Sch Med, Dept Internal Med 3, Sakuragaoka 8-35-1, Kagoshima 890, Japan Kagoshima Univ Sakuragaoka 8-35-1 Kagoshima Japan 890 0, Japan
Citazione:
F. Umehara et al., "Axonal damage revealed by accumulation of beta-amyloid precursor protein in HTLV-I-associated myelopathy", J NEUR SCI, 176(2), 2000, pp. 95-101

Abstract

We investigated the localization and extent of beta-amyloid precursor protein (APP) immunoreactivity as a sensitive marker for impairment of fast axonal transport in the spinal cords of patients with HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). The results from this study show that APP, used as a marker of early axonal damage in HAM/TSP lesions, is more intensively expressed in areas of active-inflammatory lesions than those of inactive-chronic lesions. The close localization to the areas containing inflammation (activation of macrophage/microglia) is striking and suggests that axonal damage is closely associated with inflammation in active-chronic lesions. Although inflammatory cell infiltration in the central nervous system (CNS) is rarely found in inactive-chronic lesions, a few clusters of APP+ axons are found in the spinal cord white matter in some cases. The presence of APP+ axons without relation to inflammatory cells in inactive-chronic lesions, suggest that soluble neurotoxic factors might induce axonal changes in the CNS of HAM/TSP. The occasional myelinated fibers in theanterior and posterior spinal roots in lower thoracic to lumbar levels hadAPP+ axons, suggesting that spinal nerve roots can be affected in HAM/TSP,especially in lower thoracic to lumbar levels. Impairment of fast axonal transport may contribute to the development of disability in patients with HAM/TSP. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 06/04/20 alle ore 08:51:02