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Titolo:
Endothelin A receptor blockade prevents capillary/myocyte mismatch in the heart of uremic animals
Autore:
Amann, K; Munter, K; Wessels, S; Wagner, J; Balajew, V; Hergenroder, S; Mall, G; Ritz, E;
Indirizzi:
Univ Erlangen Nurnberg, Dept Pathol, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany Univ Heidelberg, Dept Pathol, D-6900 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-6900 ol, D-6900 Heidelberg, Germany Tech Univ Darmstadt, Dept Pathol, D-64287 Darmstadt, Germany Tech Univ Darmstadt Darmstadt Germany D-64287 D-64287 Darmstadt, Germany Univ Heidelberg, Dept Internal Med, D-6900 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-6900 ed, D-6900 Heidelberg, Germany Knoll AG, D-6700 Ludwigshafen, Germany Knoll AG Ludwigshafen Germany D-6700 ll AG, D-6700 Ludwigshafen, Germany
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
fascicolo: 9, volume: 11, anno: 2000,
pagine: 1702 - 1711
SICI:
1046-6673(200009)11:9<1702:EARBPC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED CARDIAC-HYPERTROPHY; GENE-EXPRESSION; ANGIOTENSIN-II; CORONARY CAPILLARIES; RAT CARDIOMYOCYTES; RENAL-FAILURE; IN-VIVO; GROWTH; MYOCARDIUM; ANTAGONISTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Amann, K Univ Erlangen Nurnberg, Dept Pathol, Krankenhausstr 8-10, D-91054Erlangen, Germany Univ Erlangen Nurnberg Krankenhausstr 8-10 Erlangen Germany D-91054
Citazione:
K. Amann et al., "Endothelin A receptor blockade prevents capillary/myocyte mismatch in the heart of uremic animals", J AM S NEPH, 11(9), 2000, pp. 1702-1711

Abstract

In the heart of uremic animals and patients, the number of capillaries pervolume of myocardium is reduced. Immunohistochemical studies demonstrated increased cardiac endothelin-1 (ET-1) expression in the left ventricle of uremic animals. Therefore, whether treatment with a selective ETA-receptor antagonist prevented such capillary-myocyte mismatch was investigated. Twenty-four h after subtotal nephrectomy, rats were left untreated or started ontreatment with the ETA-receptor antagonist LU 135252 (20 mg/kg per d) and with the angiotensin-converting enzyme (ACE) inhibitor trandolapril (0.3 mg/kg per d), respectively. BP was monitored by telemetry. Myocardial capillary length density was analyzed by stereologic techniques that avoid anisotropy artifacts. In addition, cardiac ET-1 protein and mRNA were measured using immunohistochemistry, in situ hybridization, and quantitative reverse transcription-PCR. Changes in cardiac ETA- and ETB-receptor mRNA were measured using reverse transcription-PCR. Fifteen wk after subtotal nephrectomy, significantly reduced left ventricular capillary length density (3307 +/- 535 mm/mm(3)) was found compared with sham-operated controls (3995 +/- 471 mm/mm(3)); this was also seen in animals that were treated with trandolapril (3503 +/- 533 mm/mm(3)) but not in animals that were treated with LU 135252(3800 +/- 303 mm/mm(3)). The results support a role of ET-1 in the genesisof left ventricular capillary/myocyte mismatch in uremia.

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Documento generato il 13/07/20 alle ore 06:07:37