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Titolo:
HLA-DRB1 genes, rheumatoid factor, and elevated C-reactive protein: Independent risk factors of radiographic progression in early rheumatoid arthritis
Autore:
Listing, J; Rau, R; Muller, B; Alten, R; Czerwony, G; Gromnica-Ihle, E; Hagemann, D; Zink, A;
Indirizzi:
German Rheumatism Res Ctr, Epidemiol Unit, D-10115 Berlin, Germany German Rheumatism Res Ctr Berlin Germany D-10115 D-10115 Berlin, Germany Evangelisches Fachkrankenhaus, Ratingen, Germany Evangelisches Fachkrankenhaus Ratingen Germany nhaus, Ratingen, Germany Schlosspk Hosp, Berlin, Germany Schlosspk Hosp Berlin GermanySchlosspk Hosp, Berlin, Germany Med Ctr Rheumatol, Berlin, Germany Med Ctr Rheumatol Berlin GermanyMed Ctr Rheumatol, Berlin, Germany
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 9, volume: 27, anno: 2000,
pagine: 2100 - 2109
SICI:
0315-162X(200009)27:9<2100:HGRFAE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA-DR ANTIGENS; DISEASE-ACTIVITY; PHYSICAL-DISABILITY; PROGNOSTIC FACTORS; 2 SUBSETS; SEVERITY; ASSOCIATION; DAMAGE; SUSCEPTIBILITY; MARKERS;
Keywords:
rheumatoid arthritis; radiographic outcome; risk factors; HLA genotype; C-reactive protein; rheumatoid factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Listing, J German Rheumatism Res Ctr, Epidemiol Unit, Hannoversche Str 27,D-10115 Berlin, Germany German Rheumatism Res Ctr Hannoversche Str 27 Berlin Germany D-10115
Citazione:
J. Listing et al., "HLA-DRB1 genes, rheumatoid factor, and elevated C-reactive protein: Independent risk factors of radiographic progression in early rheumatoid arthritis", J RHEUMATOL, 27(9), 2000, pp. 2100-2109

Abstract

Objective. To evaluate the prognostic value of HLA-DRB1 antigens, rheumatoid factor (RF), and C-reactive protein (CRP) with the radiographic outcome of rheumatoid arthritis (RA). Methods. In total, 139 patients with early RA (< 2 years) were followed up. At the end of 3 year treatment with disease modifying antirheumatic drugs(DMARD) HLA genotyping and external radiographic scoring were performed. The time up to the first development of erosive disease [Ratingen radiographic score (RS) > 0, > 5, > 10] was compared by methods of survival analysis. Results. At 4 years' disease duration, DRB1*04 or DRB1*01 positive patients had RS > 0 or > 10 (73% and 27%, respectively) significantly more frequently than DRB1*04 or DRB1*01 negative patients (37% and 7%, respectively). Nearly independently of the genetic predisposition, RF and elevated CRP at the start of DMARD treatment were predictive for erosive RA at 4 years. Elevated CRP (greater than or equal to 15 mg/l) increased the probability of erosive RA in DRB1*04 or DRB1*01 positive patients from 64.0% (in patients with CRP < 15 mg/l) to 83.9%, and in DRB1*04 and DRB1*01 negative patients from 18.8% to 70.1%. The corresponding figures for RF+ and RF- patients were 58.2% and 82.5% in HLA predisposed patients and 23.5% and 60.2% in those who were negative for DRB1*04 and DRB1*01. The probability of a RS > 10 was 40.9% for HLA predisposed patients with elevated CRP. In contrast, no case with RS > 10 was found in 43 patients who had neither of these 2, risk factors. Conclusion. Our findings support that HLA predisposition plays an important role with regard to radiographic progression. However, this effect is modified by RF serum concentration and disease activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:00:26