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Titolo:
Dietary psyllium increases expression of ileal apical sodium-dependent bile acid transporter mRNA coordinately with dose-responsive changes in bile acid metabolism in rats
Autore:
Buhman, KK; Furumoto, EJ; Donkin, SS; Story, JA;
Indirizzi:
Purdue Univ, Dept Foods & Nutr, W Lafayette, IN 47907 USA Purdue Univ W Lafayette IN USA 47907 ds & Nutr, W Lafayette, IN 47907 USA Purdue Univ, Dept Anim Sci, W Lafayette, IN 47907 USA Purdue Univ W Lafayette IN USA 47907 Anim Sci, W Lafayette, IN 47907 USA
Titolo Testata:
JOURNAL OF NUTRITION
fascicolo: 9, volume: 130, anno: 2000,
pagine: 2137 - 2142
SICI:
0022-3166(200009)130:9<2137:DPIEOI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLESTEROL 7-ALPHA-HYDROXYLASE ACTIVITY; NUCLEAR RECEPTOR; LOWERING ACTION; MESSENGER-RNA; MECHANISMS; HAMSTER; CLONING; CHOLESTYRAMINE; ENZYMES; PECTIN;
Keywords:
psyllium; bile acid absorption; synthesis and excretion; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Story, JA Purdue Univ, Dept Foods & Nutr, W Lafayette, IN 47907 USA PurdueUniv W Lafayette IN USA 47907 W Lafayette, IN 47907 USA
Citazione:
K.K. Buhman et al., "Dietary psyllium increases expression of ileal apical sodium-dependent bile acid transporter mRNA coordinately with dose-responsive changes in bile acid metabolism in rats", J NUTR, 130(9), 2000, pp. 2137-2142

Abstract

Psyllium (PSY), a type of dietary fiber containing mainly soluble components, has been shown to decrease serum cholesterol concentrations in several species; however, mechanisms involved are not clearly defined. Four groups of 10 rats were fed sem purified diets containing 10% dietary fiber from cellulose and/or PSY for 21 d. Increasing levels of PSY were fed (0,3.33, 6.67 and 10% PSY) with the remaining 10% made up with cellulose. Liver cholesterol, cholesterol 7 alpha-hydroxylase (CYP7A) activity and mRNA, 3-hydroxy-3-methylglutaryl CoA reductase (HMGR) mRNA, ileal apical sodium-dependent bile acid transporter (ASBT) mRNA, fecal bile acids and total steroids, and intestinal bile acid content were measured. All variables responded in a dose-dependent manner to PSY in the diet. Total liver cholesterol content wassignificantly reduced in all groups fed PSY compared to cellulose-fed controls [138(a), 105(b), 105(b) ard 93(c) mu mol (SEM = 4.2) for 0, 3.33, 6.67and 10% PSY, respectively]. Activity of CYP7A was significantly greater inall groups fed PSY compared to the cellulose-fed controls [6.36(c), 16.92(b), 15.28(b) and 20.37(a) pmol . min(-1) . mg protein(-1) (SEM = 3.19) for 0, 3.33, 6.67 and 10% PSY, respectively]. These differences in CYP7A activity were similar to differences in CYP7A, HMGR and ASBT mRNA levels. Fecal bile acid and total steroid excretion as well as total intestinal bile acidswere significantly greater in rats fed PSY-containing diets compared to 0%PSY-fed rats. These results suggest that the reduction in liver cholesterol involves modulating the size and composition of the bile acid pool via regulation of ileal ASBT, CYP7A and HMGR mRNA levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:02:07