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Titolo:
Neural measurement of sound duration: Control by excitatory-inhibitory interactions in the inferior colliculus
Autore:
Casseday, JH; Ehrlich, D; Covey, E;
Indirizzi:
Univ Washington, Dept Psychol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Psychol, Seattle, WA 98195 USA Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA Duke Univ DurhamNC USA 27710 d Ctr, Dept Neurobiol, Durham, NC 27710 USA
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 3, volume: 84, anno: 2000,
pagine: 1475 - 1487
SICI:
0022-3077(200009)84:3<1475:NMOSDC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIG BROWN BAT; MEDIAL SUPERIOR OLIVE; EPTESICUS-FUSCUS; LATERAL LEMNISCUS; MOUSTACHED BAT; ECHOLOCATING BAT; NEURONS; SELECTIVITY; ADAPTATIONS; NUCLEI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Casseday, JH Univ Washington, Dept Psychol, Box 351525, Seattle, WA 98195 USA Univ Washington Box 351525 Seattle WA USA 98195 WA 98195 USA
Citazione:
J.H. Casseday et al., "Neural measurement of sound duration: Control by excitatory-inhibitory interactions in the inferior colliculus", J NEUROPHYS, 84(3), 2000, pp. 1475-1487

Abstract

In the inferior colliculus (IC) of the big brown bat, a subpopulation of cells (similar to 35%) are tuned to a narrow range of sound durations. Band-pass tuning for sound duration has not been seen at lower levels of the auditory pathway. Previous work suggests that it arises at the IC through the interaction of sound-evoked, temporally offset, excitatory and inhibitory inputs. To test this hypothesis, we recorded from duration-tuned neurons in the IC and examined duration tuning before and after iontophoretic infusionof antagonists to gamma-aminobutyric acid-A (GABA(A)) (bicuculline) or glycine (strychnine). The criterion for duration tuning was that the neuron's spike count as a function of duration had a peak value at one duration or arange of durations that was greater than or equal to 2 times the lowest nonzero value at longer durations. Out of 21 units tested with bicuculline, duration tuning was eliminated in 15, broadened in two, and unaltered in four. Out of 10 units tested with strychnine, duration tuning was eliminated in four, broadened in one, and unaltered in five. For units tested with bothbicuculline and strychnine, bicuculline had a greater effect on reducing or abolishing duration tuning than did strychnine. Bicuculline and strychnine both produced changes in discharge pattern. There was nearly always a shift from an offset response to an onset response, indicating that in the predrug condition, inhibition arrived simultaneously with excitation or preceded it. There was often an increase in the length of the spike train, indicating that in the predrug condition, inhibition also coincided with later parts of excitation. These findings support two hypotheses. First, duration tuning is created in the IC. Second, although the construction of duration tuning varies in some details among IC neurons, it follows three rules: 1) an excitatory and an inhibitory event are temporally linked to the onset of sound but temporally offset from one another; 2) the duration of some inhibitory event must be linked to the duration of the sound; 3) an excitatory event must be linked to the offset of sound.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:36:08