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Titolo:
Dendrosomatic voltage and charge transfer in rat neocortical pyramidal cells in vitro
Autore:
Ulrich, D; Stricker, C;
Indirizzi:
Univ Zurich, Inst Neuroinformat, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 rmat, CH-8057 Zurich, Switzerland Swiss Fed Inst Technol, CH-8057 Zurich, Switzerland Swiss Fed Inst Technol Zurich Switzerland CH-8057 57 Zurich, Switzerland
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 3, volume: 84, anno: 2000,
pagine: 1445 - 1452
SICI:
0022-3077(200009)84:3<1445:DVACTI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORIMOTOR CORTEX INVITRO; EXCITATORY POSTSYNAPTIC POTENTIALS; NEURONS IN-VITRO; LAYER-V NEURONS; VISUAL-CORTEX; DENDRITIC MORPHOLOGY; CONDUCTANCE TRANSIENTS; SYNAPTIC POTENTIALS; APICAL DENDRITES; DYNAMIC CLAMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Ulrich, D Univ Bern, Dept Physiol, Buhlpl 5, CH-3012 Bern, Switzerland Univ Bern Buhlpl 5 Bern Switzerland CH-3012 2 Bern, Switzerland
Citazione:
D. Ulrich e C. Stricker, "Dendrosomatic voltage and charge transfer in rat neocortical pyramidal cells in vitro", J NEUROPHYS, 84(3), 2000, pp. 1445-1452

Abstract

Most excitatory synapses on neocortical pyramidal cells are located on dendrites, which are endowed with a variety of active conductances. The main origin for action potentials is thought to be at the initial segment of the axon, although local regenerative activity can be initiated in the dendrites. The transfer characteristics of synaptic voltage and charge along the dendrite to the soma remains largely unknown, although this is an essential determinant of neural input-output transformations. Here we perform dual whole-cell recordings from layer V pyramidal cells in slices from somatosensory cortex of juvenile rats. Steady-state and sinusoidal current injections are applied to characterize the voltage transfer characteristics of the apical dendrite under resting conditions. Furthermore, dendrosomatic charge andvoltage transfer are determined by mimicking synapses via dynamic current-clamping. We find that around rest, the dendrite behaves like a linear cable. The cutoff frequency for somatopetal current transfer is around 4 Hz, i.e., synaptic inputs are heavily low-pass filtered. In agreement with linearity, transfer resistances are reciprocal in opposite directions, and the centroids of the synaptic time course are on the order of the membrane time constant. Transfer of excitatory postsynaptic potential (EPSP) charge, but not peak amplitude, is positively correlated with membrane potential. We conclude that the integrative properties of dendrites in infragranular neocortical pyramidal cells appear to be linear near resting membrane potential. However, at polarized potentials charge transferred is voltage-dependent with a loss of charge at hyperpolarized and a gain of charge at depolarized potentials.

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Documento generato il 15/07/20 alle ore 14:35:41