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Titolo:
Enzymes and abzymes relationships
Autore:
Avalle, B; Friboulet, A; Thomas, D;
Indirizzi:
Univ Technol Compiegne, CNRS, UPRESA 6022, F-60205 Compiegne, France Univ Technol Compiegne Compiegne France F-60205 -60205 Compiegne, France
Titolo Testata:
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
fascicolo: 1-3, volume: 10, anno: 2000,
pagine: 39 - 45
SICI:
1381-1177(20000904)10:1-3<39:EAAR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; TRANSITION-STATE ANALOG; ANTIBODY LIGHT-CHAIN; BENCE-JONES PROTEINS; CATALYTIC ANTIBODIES; ANTIIDIOTYPIC ANTIBODIES; 3-DIMENSIONAL STRUCTURE; AUTOIMMUNE-DISEASES; MONOCLONAL-ANTIBODY; CRYSTAL-STRUCTURE;
Keywords:
catalytic antibodies; abzymes; anti-idiotypic antibodies; metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Thomas, D Univ Technol Compiegne, CNRS, UPRESA 6022, BP 20529, F-60205 Compiegne, France Univ Technol Compiegne BP 20529 Compiegne France F-60205 France
Citazione:
B. Avalle et al., "Enzymes and abzymes relationships", J MOL CAT B, 10(1-3), 2000, pp. 39-45

Abstract

Antibodies and enzymes are proteins that bind macromolecules and small natural and synthetic ligands with high specificity and high affinity. While enzymes have been perfecting their skills during evolution to reach very efficient structures for catalysis, antibody-binding sites evolve toward efficient structures for binding in a few weeks. The generation of antibodies bearing catalytic activities (abzymes) brings new insights in the understanding on the evolution of the catalytic function, and also on functions that the immune system could play in metabolism. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 05:04:30