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Titolo:
HIV-1 genotypes in peripheral blood monocytes
Autore:
Zhu, TF;
Indirizzi:
Univ Washington, Dept Lab Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Lab Med, Seattle, WA 98195 USA
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 3, volume: 68, anno: 2000,
pagine: 338 - 344
SICI:
0741-5400(200009)68:3<338:HGIPBM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; CD4(+) T-CELLS; MONONUCLEAR PHAGOCYTES; TYPE-1 INFECTION; GENETIC RESTRICTION; DISEASE PROGRESSION; ENVELOPE PROTEIN; VIRAL PHENOTYPE; RHESUS-MONKEYS;
Keywords:
HIV-1; genotype; CD14(+) monocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Zhu, TF Univ Washington, Dept Lab Med, POB 357110,1959 NE Pacific St, Seattle, WA 98195 USA Univ Washington POB 357110,1959 NE Pacific St Seattle WA USA 98195
Citazione:
T.F. Zhu, "HIV-1 genotypes in peripheral blood monocytes", J LEUK BIOL, 68(3), 2000, pp. 338-344

Abstract

CD4(+) T cells and tissue macrophages are well de fined as the major targets for human immunodeficiency virus type 1 (HIV-1) infection and replication, and their infection accounts for many aspects of HIV-1 pathogenesis in vivo. HIV-1 genotype and phenotype in monocytes and their potential roles inpathogenicity in vivo remain unknown. Herein is an overview of our initialwork on HIV-1 genotype in purified CD14(+) monocytes isolated longitudinally during the course of infection starting from the time of infection. Our data provide evidence for HIV-1 evolution in monocytes and their role as a reservoir of HIV-1 in vivo. A better understanding of HIV-1 in monocytes may greatly help the development of new therapeutic strategies for HIV-1 infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:42:42