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Titolo:
ANTIALLERGIC PROPERTIES OF THE NATURAL PAF ANTAGONIST YANGAMBIN
Autore:
SERRA MF; DIAZ BL; BARRETO EO; PEREIRA APB; LIMA MCR; BARBOSAFILHO JM; CORDEIRO SB; MARTINS MA; DESILVA PMR;
Indirizzi:
FIOCRUZ MS,INST OSWALDO CRUZ,DEPT FISIOL & FARMACODINAM,AV BRASIL 4365,CAIXA POSTAL 926 BR-21045900 RIO JANEIRO BRAZIL FIOCRUZ MS,INST OSWALDO CRUZ,DEPT FISIOL & FARMACODINAM BR-21045900 RIO JANEIRO BRAZIL UNIV FED PARAIBA,LAB TECNOL FARMACEUT BR-58059900 JOAO PESSOA PARAIBABRAZIL
Titolo Testata:
Planta medica
fascicolo: 3, volume: 63, anno: 1997,
pagine: 207 - 212
SICI:
0032-0943(1997)63:3<207:APOTNP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-ACTIVATING-FACTOR; ACTIVELY SENSITIZED RATS; FACTOR RECEPTOR ANTAGONIST; PHARMACOLOGICAL MODULATION; ACETHER; ANAPHYLAXIS; PLEURISY; AZELASTINE; OVALBUMIN;
Keywords:
YANGAMBIN; PAF; ANTIGEN; PLEURISY; SYSTEMIC ANAPHYLAXIS; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
M.F. Serra et al., "ANTIALLERGIC PROPERTIES OF THE NATURAL PAF ANTAGONIST YANGAMBIN", Planta medica, 63(3), 1997, pp. 207-212

Abstract

In this study we examined the ability of the furofuran lignan yangambin to influence the local and systemic responses induced by antigen orPAF in actively sensitized or normal rats. Given intraperitoneally Ihbefore stimulation, yangambin inhibited the pleural neutrophil and eosinophil infiltration evoked by the Lpl. injection of PAF or antigen into normal or 14 day-sensitized rats whereas plasma exudation evoked by both stimuli was unaffected. The pleural neutrophil influx (6 h) after LTB4 stimulation was also significantly inhibited by yangambin. We also evidenced that the hemoconcentration, thrombocytopenia, and leucocytosis noted after i.v. PAF were all attenuated by yangambin. In actively sensitized rats, pretreatment with yangambin failed to modify theantigen-induced hemoconcentration and leucocytosis, but dose-dependently abrogated the thrombocytopenia noted Ih post-stimulation. In vitro, the anaphylactic contraction of longitudinal jejunal segments to antigen challenge was significantly inhibited by yangambin (10(-5) - 10(-4) M), Likewise, the contraction of jejunal segments from normal rats to PAF was markedly blocked by yangambin under conditions where the response to 5-hydroxytryptamine (5-HT) was not altered. In conclusion, our results show that antigen- and PAF-induced pleural neutrophil and eosinophil accumulation, but not exudation, is sensitive to treatment with yangambin, In addition, yangambin also suppressed the pleural neutrophil infiltration triggered by LTB4 as well as the blood thrombocytopenia and intestinal anaphylaxis elicited by antigen in rats. Thus, our findings indicate that yangambin shows an antagonistic action on receptors other than those of PAF, i.e., LTB4, and strongly suggest that it may be a useful drug in the treatment of some allergic inflammatoryresponses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:55:47