Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of a reversible 'nephrectomy' on renal sympathetic activity and blood pressure in the rat: evidence for an acute angiotensin-mediated hypertension
Autore:
Recordati, G; Zorzoli, F; Zanchetti, A;
Indirizzi:
Univ Milan, Ctr Fisiol Clin & Ipertens, Ist Clin Med Gen & Terapia Med, I-20122 Milan, Italy Univ Milan Milan Italy I-20122 d Gen & Terapia Med, I-20122 Milan, Italy Osped Maggiore, IRCCS, Milan, Italy Osped Maggiore Milan ItalyOsped Maggiore, IRCCS, Milan, Italy
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 9, volume: 18, anno: 2000,
pagine: 1277 - 1287
SICI:
0263-6352(200009)18:9<1277:EOAR'O>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE UNILATERAL NEPHRECTOMY; NERVE ACTIVITY; REFLEX NATRIURESIS; RENORENAL REFLEXES; CONSCIOUS RATS; CHEMORECEPTORS; DENERVATION; KIDNEY; INCREASES; RECEPTORS;
Keywords:
sympathetic nerve activity; renal nerve activity; nephrectomy; functional nephrectomy; renal sensory innervation; renal chemoreceptors; experimental hypertension; acute renal hypertension; acute angiotensin-mediated hypertension; angiotensin converting enzyme inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Recordati, G Univ Milan, Ctr Fisiol Clin & Ipertens, Ist Clin Med Gen & Terapia Med, Via F Sforza 35, I-20122 Milan, Italy Univ Milan Via F Sforza 35Milan Italy I-20122 Milan, Italy
Citazione:
G. Recordati et al., "Effects of a reversible 'nephrectomy' on renal sympathetic activity and blood pressure in the rat: evidence for an acute angiotensin-mediated hypertension", J HYPERTENS, 18(9), 2000, pp. 1277-1287

Abstract

Objective To verify whether the normal kidney exerts a supportive, facilitatory action an renal sympathetic nerve activity (RSNA), the effects of unilateral and bilateral nephrectomy on RSNA have been studied. Methods The RSNA, rectal temperature (T), rate of breathing (RB), arterialbrood pressure (BP) and heart rate (HR) were continuously recorded in three groups of pentobarbital anaesthetized, spontaneously breathing Sprague-Dawley rats: group 1 (n = 5): both kidneys intact; group 2 (n = 5): left surgical nephrectomy; group 3 (n = 5): left surgical nephrectomy and functionalexclusion of the right kidney (functional right nephrectomy, FRN), produced by a tight ligature of the renal hilum which was maintained for 3 h. In afourth group (n = 7), in which nerve activity was not recorded, reopening of the right renal hilum was preceded or followed by intravenous administration of captopril (3 mg/kg). Results In groups 1 and 2 RSNA increased from 22.3 +/- 2.1 to 122.9 +/- 13.6 and from 26.7 +/- 1,2 to 93.2 +/- 14.0 impulses/s (mean +/- SEM), respectively, without concomitant changes in cardiovascular parameters. In group 3 RSNA decreased from 39.1 +/- 3.1 to 13.7 +/- 2.6 impulses/s during the 3 h of FRN. In group 3 the reopening of the right renal hilum was followed bya marked increase in BP and HR that was prevented or reversed by intravenous captopril in rats of group 4. Conclusions The decrease in RSNA observed in rats during bilateral nephrectomy, in contrast to the increase observed in rats with one or both kidneysintact, suggests that the kidney as a whole exerts a supportive role on sympathetic nerve activity. The hypertension and tachycardia that follows thereopening of the right kidney hilum appears to be caused by the generationof endogenous angiotensin II; this is the first evidence of an acute angiotensin-mediated renal hypertension. J Hypertens 2000, 18:1277-1287 (C) Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 19:18:31