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Titolo:
The influence of HLA genotyping compatibility on clinical outcome after cord blood transplantation from unrelated donors
Autore:
Ohnuma, K; Isoyama, K; Ikuta, K; Toyoda, Y; Nakamura, J; Nakajima, F; Nishihira, H;
Indirizzi:
Kanagawa Childrens Med Ctr, Dept Oncol, Yokohama, Kanagawa 2328555, Japan Kanagawa Childrens Med Ctr Yokohama Kanagawa Japan 2328555 2328555, Japan Showa Univ, Fujigaoka Hosp, Dept Pediat, Yokohama, Kanagawa 2278501, JapanShowa Univ Yokohama Kanagawa Japan 2278501 ohama, Kanagawa 2278501, Japan Yokohama City Univ, Sch Med, Dept Transfus Med, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Kanagawa Red Cross Blood Ctr, Div Lab 3, Yokohama, Kanagawa 2458585, JapanKanagawa Red Cross Blood Ctr Yokohama Kanagawa Japan 2458585 58585, Japan
Titolo Testata:
JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
fascicolo: 4, volume: 9, anno: 2000,
pagine: 541 - 550
SICI:
1525-8165(200008)9:4<541:TIOHGC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; HEMATOPOIETIC STEM-CELLS; PLACENTAL-BLOOD; LEUKEMIA; RECIPIENTS; CHILDREN; ANEMIA; BANK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Nishihira, H Hirado 4-27-23,Totsuk Ku, Yokohama, Kanagawa 2320802, Japan Hirado 4-27-23,Totsuk Ku Yokohama Kanagawa Japan 2320802 pan
Citazione:
K. Ohnuma et al., "The influence of HLA genotyping compatibility on clinical outcome after cord blood transplantation from unrelated donors", J HEMATH ST, 9(4), 2000, pp. 541-550

Abstract

We performed retrospective DNA typing of class I (A, B, Cw) and class II (DRB1, DQB1, DPB1) HLA alleles in 27 unrelated cord blood transplantation (CBT) cases donated from a single cord blood bank (Kanagawa Cord Blood Bank). The influence of HLA genotype matching on clinical outcome was evaluated. From Cox's model, we found that incompatibility of two or more HLA alleles between the donor and recipient of an unrelated CBT was suggested to be a risk factor for a worse event-free survival (EFS) (p = 0.04; RR, 4.06; 95% CI, 1.06-15.61), Furthermore, mismatches including HLA-DRB1 alleles had an adverse effect on EFS (p = 0.04; RR, 4.91; 95% CI, 1.01-24.02), For definiteconclusions on the role of HLA allele typing in unrelated CBT, more accumulation of data and analysis will be required.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:57:37