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Titolo:
WILLED ACTION - A FUNCTIONAL MRI STUDY OF THE HUMAN PREFRONTAL CORTEXDURING A SENSORIMOTOR TASK
Autore:
HYDER F; PHELPS EA; WIGGINS CJ; LABAR KS; BLAMIRE AM; SHULMAN RG;
Indirizzi:
YALE UNIV,DEPT BIOCHEM & MOL BIOPHYS,126 MRC,330 CEDAR ST NEW HAVEN CT 06510 YALE UNIV,DEPT PSYCHOL NEW HAVEN CT 06510 MAX PLANCK INST NEUROL RES D-04103 LEIPZIG GERMANY JOHN RADCLIFFE HOSP,MRC OXFORD OX3 9DU ENGLAND
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 13, volume: 94, anno: 1997,
pagine: 6989 - 6994
SICI:
0027-8424(1997)94:13<6989:WA-AFM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; LOCALIZATION; ACTIVATION; SELECTION; CONTRAST; ANATOMY; PET;
Keywords:
POSITRON EMISSION TOMOGRAPHY; HUMAN BRAIN MAPPING; DORSOLATERAL PREFRONTAL CORTEX; VERBAL FLUENCY; BRODMANN AREAS 6,8,9,24,32,45, AND 46);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
F. Hyder et al., "WILLED ACTION - A FUNCTIONAL MRI STUDY OF THE HUMAN PREFRONTAL CORTEXDURING A SENSORIMOTOR TASK", Proceedings of the National Academy of Sciences of the United Statesof America, 94(13), 1997, pp. 6989-6994

Abstract

Functional MRI (fMRI) was used to examine human brain activity withinthe dorsolateral prefrontal cortex during a sensorimotor task that had been proposed to require selection between several responses, a cognitive concept termed ''willed action'' in a positron emission tomography (PET) study by Frith ct al, [Frith, C. D., Friston, K., Liddle, P. E. & Frackowiak, R. S. J. (1991) Proc, R. Sec. London Ser. B 244, 241-246], We repeated their sensorimotor task, in which the subject chooses to move either of two fingers after a stimulus, by fMRI experiments in a 2.1-T imaging spectrometer, Echo-planar images were acquired fromfour coronal slices in the prefrontal cortex from nine healthy subjects, Slices were 5 mm thick, centers separated by 7 mm, with nominal in-plane spatial resolution of 9.6 x 5.0 mm(2) for mean data, Our mean results are in agreement with the PET results in that we saw similar bilateral activations, The present results are compared with our previously published fMRI study of a verbal fluency task, which had also beenproposed by Frith ct al, to elicit a ''willed action'' response, We find a clear separation of activation foci in the left dorsolateral prefrontal cortex for the sensorimotor (Brodmann area 46) and verbal fluency (Brodmann area 45) tasks, Hence, assigning a particular activated region to ''willed action'' is not supported by the fMRI data when examined closely because identical regions are not activated with different modalities, Similar modality linked activations can be observed in the original PET study but the greater resolution of the fMRI data makes the modality linkages more definite.

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Documento generato il 31/03/20 alle ore 10:30:25