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Titolo:
HOMODIMERIC AND HETERODIMERIC INTERACTIONS BETWEEN THE GENE-PRODUCTS OF PKD1 AND PKD2
Autore:
TSIOKAS L; KIM E; ARNOULD T; SUKHATME VP; WALZ G;
Indirizzi:
HARVARD UNIV,BETH ISRAEL DEACONESS MED CTR,SCH MED,DEPT MED,RENAL DIVBOSTON MA 02215 HARVARD UNIV,BETH ISRAEL DEACONESS MED CTR,SCH MED,DEPT MED,RENAL DIVBOSTON MA 02215 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,LAB MOL & DEV NEUROSCI BOSTON MA 02114
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 13, volume: 94, anno: 1997,
pagine: 6965 - 6970
SICI:
0027-8424(1997)94:13<6965:HAHIBT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYSTIC KIDNEY-DISEASE; T-CELL; TRANSGENIC MICE; 2ND GENE; PROTEIN; EXPRESSION; ACTIVATION; LOCALIZATION; CHANNELS; DOMAINS;
Keywords:
POLYCYSTIC KIDNEY DISEASE; YEAST 2-HYBRID SYSTEM; PROTEIN-PROTEIN INTERACTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
L. Tsiokas et al., "HOMODIMERIC AND HETERODIMERIC INTERACTIONS BETWEEN THE GENE-PRODUCTS OF PKD1 AND PKD2", Proceedings of the National Academy of Sciences of the United Statesof America, 94(13), 1997, pp. 6965-6970

Abstract

PKD1 and PKD2 are two recently identified genes that are responsible for the vast majority of autosomal polycystic kidney disease, a commoninherited disease that causes progressive renal failure, PKD1 encodespolycystin, a large glycoprotein that contains several extracellular motifs indicative of a role in cell-cell or cell-matrix interactions, and the PKD2 encodes a protein with homology to a voltage-activated calcium channel and to PKD1, It is currently unknown how mutations of either protein functionally cause autosomal polycystic kidney disease. We show that PKD1 and PKD2 interact through their C-terminal cytoplasmic tails. This interaction resulted in an up-regulation of PKD1 but notPKD2, Furthermore, the cytoplasmic tail of PKD2 but not PKD1 formed homodimers through a coiled-coil domain distinct from the region required for interaction with PKD1, These interactions suggest that PKD1 andPKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis and that PKD1 may require the presence of PKD2 for stable expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:47:50