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Titolo:
LIGAND-BINDING WAS ACQUIRED DURING EVOLUTION OF NUCLEAR RECEPTORS
Autore:
ESCRIVA H; SAFI R; HANNI C; LANGLOIS MC; SAUMITOULAPRADE P; STEHELIN D; CAPRON A; PIERCE R; LAUDET V;
Indirizzi:
INST PASTEUR,CNRS,UMR MECAN DEV & CANCERISAT 319,1 CALMETTE F-59019 LILLE FRANCE INST PASTEUR,CNRS,UMR MECAN DEV & CANCERISAT 319 F-59019 LILLE FRANCE INST PASTEUR,INSERM,U167 RELAT HOTE PARASITE & STRATEGIES VACCINALES F-59019 LILLE FRANCE UNIV LILLE 1,CNRS,URA GENET EVOLUT POPULAT VEGETALES 1185 F-59655 VILLENEUVE DASCQ FRANCE
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 13, volume: 94, anno: 1997,
pagine: 6803 - 6808
SICI:
0027-8424(1997)94:13<6803:LWADEO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATION; SEQUENCES; REVEALS; ORIGIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
H. Escriva et al., "LIGAND-BINDING WAS ACQUIRED DURING EVOLUTION OF NUCLEAR RECEPTORS", Proceedings of the National Academy of Sciences of the United Statesof America, 94(13), 1997, pp. 6803-6808

Abstract

The nuclear receptor (NR) superfamily comprises, in addition to ligand-activated transcription factors, members for which no ligand has been identified to date. We demonstrate that orphan receptors are randomly distributed in the evolutionary tree and that there is no relationship between the position of a given liganded receptor in the tree and the chemical nature of its ligand. NRs are specific to metazoans, as revealed by a screen of NR-related sequences in early- and non-metazoan organisms, The analysis of the NR gene duplication pattern during the evolution of metazoans shows that the present NR diversity arose from two waves of gene duplications, Strikingly, our results suggest that the ancestral NR was an orphan receptor that acquired ligand-binding ability during subsequent evolution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 11:23:38