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Titolo:
Dizygotic twinning is not linked to variation at the alpha-inhibin locus on human chromosome 2
Autore:
Montgomery, GW; Duffy, DL; Hall, J; Haddon, BR; Kudo, M; McGee, EA; Palmer, JS; Hsueh, AJ; Boomsma, DI; Martin, NG;
Indirizzi:
Royal Brisbane Hosp, Queensland Inst Med Res, Genet Epidemiol Lab, Brisbane, Qld 4029, Australia Royal Brisbane Hosp Brisbane Qld Australia 4029 bane, Qld 4029, Australia Univ Queensland, Joint Genet Program, Brisbane, Qld 4029, Australia Univ Queensland Brisbane Qld Australia 4029 Brisbane, Qld 4029, Australia AxyS Pharmaceut Inc, La Jolla, CA 92037 USA AxyS Pharmaceut Inc La Jolla CA USA 92037 eut Inc, La Jolla, CA 92037 USA Stanford Univ, Med Ctr, Dept Gynecol & Obstet, Div Reprod Biol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 v Reprod Biol, Stanford, CA 94305 USA Free Univ Amsterdam, Dept Psychol, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam Amsterdam Netherlands NL-1081 HV terdam, Netherlands
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 9, volume: 85, anno: 2000,
pagine: 3391 - 3395
SICI:
0021-972X(200009)85:9<3391:DTINLT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; OVULATION RATE; PASSIVE-IMMUNIZATION; ACTIVE IMMUNIZATION; LINKAGE ANALYSIS; TWINS; MOTHERS; SHEEP; RECEPTOR; PEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Montgomery, GW Royal Brisbane Hosp, Queensland Inst Med Res, Genet Epidemiol Lab, PO, Brisbane, Qld 4029, Australia Royal Brisbane Hosp PO Brisbane Qld Australia 4029 ustralia
Citazione:
G.W. Montgomery et al., "Dizygotic twinning is not linked to variation at the alpha-inhibin locus on human chromosome 2", J CLIN END, 85(9), 2000, pp. 3391-3395

Abstract

Natural multiple pregnancy in women leading to dizygotic (DZ) twins is familial and varies across racial groups, suggesting a genetic predisposition. Mothers of DZ twins have a higher incidence of spontaneous multiple ovulation and elevated FSH concentrations. FSH release is controlled by feedback of inhibin peptides from the ovary, and immunization against inhibin alpha-subunit results in an increased ovulation rate in animals. The inhibin alpha-subunit is therefore a candidate gene for mutations that may increase thefrequency of DZ twinning. Restriction digests of a PCR product from exon 1with the enzyme SpeI detects a C/T polymorphism at bp 128 with two allelesof 447 and 323/124 bp. The polymorphism was typed in 1125 individuals from326 pedigrees with 717 mothers of spontaneous DZ twins. The alpha-inhibin locus mapped within 3 centimorgans of D2S164, and Linkage with DZ twinning was excluded [decimal log odds ratio (LOD) score, -2.81 at theta = 0]. There was complete exclusion of linkage (LOD, less than -2) of a gene conferring relative risk 1.8 (lambda s, >1.8) across the chromosome, except at the p-terminus region and a small peak (maximum LOD score, 0.6) in the region ofD2S151-D2S326. Analysis using either recessive or dominant models excludedlinkage with DZ twinning in this population (LOD score, less than -2.5) across chromosome 2. We conclude that dizygotic twinning is not linked to variation in the alpha-inhibin locus. The results also suggest that mutations in other candidates on chromosome 2, including the receptor for FSH and thebeta(B)-inhibin subunit (INHBB) cannot be major contributors to risk for DZ twinning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/02/20 alle ore 14:40:31