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Titolo:
Dehydroepiandrosterone replacement administration: Pharmacokinetic and pharmacodynamic studies in healthy elderly subjects
Autore:
Legrain, S; Massien, C; Lahlou, N; Roger, M; Debuire, B; Diquet, B; Chatellier, G; Azizi, M; Faucounau, V; Porchet, H; Forette, F; Baulieu, EE;
Indirizzi:
Hop Bichat, Serv Geriat, F-94276 Le Kremlin Bicetre, France Hop Bichat LeKremlin Bicetre France F-94276 Le Kremlin Bicetre, France Hop Broussais, Ctr Invest Clin, F-94276 Le Kremlin Bicetre, France Hop Broussais Le Kremlin Bicetre France F-94276 Kremlin Bicetre, France Hop St Vincent de Paul, F-94276 Le Kremlin Bicetre, France Hop St Vincent de Paul Le Kremlin Bicetre France F-94276 Bicetre, France Hop Paul Brousse, Serv Biochim, F-94276 Le Kremlin Bicetre, France Hop Paul Brousse Le Kremlin Bicetre France F-94276 emlin Bicetre, France Hop La Pitie Salpetriere, Serv Pharmacol, F-94276 Le Kremlin Bicetre, France Hop La Pitie Salpetriere Le Kremlin Bicetre France F-94276 cetre, France Fdn Natl Gerontol, F-94276 Le Kremlin Bicetre, France Fdn Natl Gerontol Le Kremlin Bicetre France F-94276 mlin Bicetre, France Debiopharm, F-94276 Le Kremlin Bicetre, France Debiopharm Le Kremlin Bicetre France F-94276 Le Kremlin Bicetre, France Hop Broca, Serv Gerontol, F-94276 Le Kremlin Bicetre, France Hop Broca LeKremlin Bicetre France F-94276 6 Le Kremlin Bicetre, France Coll France, INSERM, U488, F-94276 Le Kremlin Bicetre, France Coll FranceLe Kremlin Bicetre France F-94276 Le Kremlin Bicetre, France
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 9, volume: 85, anno: 2000,
pagine: 3208 - 3217
SICI:
0021-972X(200009)85:9<3208:DRAPAP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEHYDROISOANDROSTERONE SULFATE; ORAL DEHYDROEPIANDROSTERONE; POSTMENOPAUSAL WOMEN; SEX-DIFFERENCES; NORMAL MEN; METABOLISM; SERUM; DHEA; AGE; ESTROGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Baulieu, EE INSERM, U488 Steroides & Syst Nerveux, 80 Rue Gen Leclerc, F-94276 Le Kremlin Bicetre, France INSERM 80 Rue Gen Leclerc Le Kremlin Bicetre France F-94276 e
Citazione:
S. Legrain et al., "Dehydroepiandrosterone replacement administration: Pharmacokinetic and pharmacodynamic studies in healthy elderly subjects", J CLIN END, 85(9), 2000, pp. 3208-3217

Abstract

Dehydroepiandrosterone (DHEA; 50 and 25 mg) and placebo tablets were orally administered daily to 24 healthy aging men and women (67.8 +/- 4.3 yr) for 8 days according to a balanced incomplete block design. Nine blood tests on both the first and eighth days allowed the measurement of DHEA, its sulfate DHEAS, and metabolites: testosterone, 5 alpha-androstan-3 alpha,17 beta-diol glucuronide, estradiol, and estrone. Relatively low background levelsof DHEA(S) were observed, and with the reestablishment of "young" levels, four important results were obtained. 1) Blood DHEA had an apparent terminal half-life of more than 20 h, the same order of magnitude as that of bloodDHEAS, a result explainable by back-hydrolysis of the large amount of DHEAS formed after oral administration of DHEA, a mechanism providing long-lived unconjugated DHEA and metabolites. 2) The metabolic conversion of DHEAS to DHEA was significantly greater in women than in men. 3) No accumulation of steroids was observed. 4) No worrying transformation to androgen and estrogen was recorded; indeed, the limited increased estradiol in aged women could be predicted to be beneficial. These results suggested that daily oral administration of DHEA (25/50 mg) is safe in elderly subjects. The 50-mg dose was chosen for a 1 yr, double blind, placebo-controlled trial of daily oral administration of DHEA in 60- to 80-yr-old individuals (DHEAge).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 18:49:03