Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
OLIGODENDROGLIOMAS .2. A NEW GRADING SYSTEM BASED ON MORPHOLOGICAL AND IMAGING CRITERIA
Autore:
DAUMASDUPORT C; TUCKER ML; KOLLES H; CERVERA P; BEUVON F; VARLET P; UDO N; KOZIAK M; CHODKIEWICZ JP;
Indirizzi:
CTR HOSP ST ANNE,ANAT PATHOL LAB,1 RUE CABANIS F-75674 PARIS 14 FRANCE HOP ST ANNE,DEPT PATHOL NEUROONCOL F-75674 PARIS FRANCE HOP ST ANNE,DEPT NEUROSURG F-75674 PARIS FRANCE FAC COCHIN PORT ROYAL PARIS FRANCE
Titolo Testata:
Journal of neuro-oncology
fascicolo: 1, volume: 34, anno: 1997,
pagine: 61 - 78
SICI:
0167-594X(1997)34:1<61:O.ANGS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTOPERATIVE IRRADIATION; CENTRAL NEUROCYTOMA; GLIAL NEOPLASMS; EXPERIENCE; PROGNOSIS; GLIOMAS;
Keywords:
OLIGODENDROGLIOMA; GRADING SYSTEM; PROGNOSTIC FACTORS; OUTCOME; RADIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
C. Daumasduport et al., "OLIGODENDROGLIOMAS .2. A NEW GRADING SYSTEM BASED ON MORPHOLOGICAL AND IMAGING CRITERIA", Journal of neuro-oncology, 34(1), 1997, pp. 61-78

Abstract

This second part of our study of 'pure' oligodendrogliomas focuses onsurvival data analysis. In order to identify potentially useful prognostic factors and to assess the effectiveness of a new grading system,the 79 patients in the previously analyzed series for whom adequate follow-up could be obtained (52%) were entered in the present analysis. Statistical analysis demonstrated that contrast enhancement and endothelial hyperplasia had powerful and similar influence on survival. Median survival with and without contrast enhancement were: 3 versus 11 years, and with or without endothelial hyperplasia were: 3.5 versus 11 years. Conversely, the degree of nuclear atypia and presence or absence of mitosis or necrosis were not correlated with survival. These findings allowed us to devise a simple grading system which discriminates two malignancy grades as follows: absence of endothelial hyperplasia and of contrast enhancement = Grade A, presence of endothelial hyperplasia and/or of contrast enhancement = Grade B. Of the 79 oligodendrogliomas in this study 59 tumors were categorized as grade A and 20 as grade B. Median survival were: 11 years in grade A and 3.5 years in gradeB. Five-year and 8-year survival rates were: 89% and 60% in grade A and: 33% and 15% in grade B. Double blind grading between two independent observers was concordant in 96% of the cases. Application of this simple efficient and reproducible grading scheme should permit reliablecomparison of retrospective or prospective therapeutic data emanatingfrom various institutions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:11:12