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Titolo:
Series-to-parallel transition in the filament lattice of airway smooth muscle
Autore:
Seow, CY; Pratusevich, VR; Ford, LE;
Indirizzi:
Indiana Univ, Sch Med, Krannert Inst Cardiol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ardiol, Indianapolis, IN 46202 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 89, anno: 2000,
pagine: 869 - 876
SICI:
8750-7587(200009)89:3<869:STITFL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-RAY-DIFFRACTION; SHORTENING VELOCITY; MYOSIN-FILAMENTS; ISOMETRIC FORCE; CONTRACTION; FIBERS; EXTENSIBILITY; ANOCOCCYGEUS; ACTIVATION; STIFFNESS;
Keywords:
sheep; smooth muscle activation; smooth muscle contraction; muscle velocity; myosin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Seow, CY Univ British Columbia, Dept Pharmacol Therapeut, 2176 Hlth Sci Mall, Vancouver, BC V6T 1Z3, Canada Univ British Columbia 2176 Hlth Sci Mall Vancouver BC Canada V6T 1Z3
Citazione:
C.Y. Seow et al., "Series-to-parallel transition in the filament lattice of airway smooth muscle", J APP PHYSL, 89(3), 2000, pp. 869-876

Abstract

Force-velocity curves measured at different times during tetani of sheep trachealis muscle were analyzed to assess whether velocity slowing could be explained by thick-filament lengthening. Such lengthening increases force by placing more cross bridges in parallel on longer filaments and decreases velocity by reducing the number of filaments spanning muscle length. From 2s after the onset of stimulation, when force had achieved 42% of it final value, to 28 s, when force had been at its tetanic plateau for similar to 15 s, velocity decreases were exactly matched by force increases when force was adjusted for changes in activation, as assessed from the maximum power value in the force-velocity curves. A twofold change in velocity could be quantitatively explained by a series-to-parallel change in the filament lattice without any need to postulate a change in cross-bridge cycling rate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:59:20