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Titolo:
Interaction of methadone with didanosine and stavudine
Autore:
Rainey, PM; Friedland, G; McCance-Katz, EF; Andrews, L; Mitchell, SM; Charles, C; Jatlow, P;
Indirizzi:
Yale Univ, Sch Med, Dept Lab Med, New Haven, CT USA Yale Univ New Haven CT USA niv, Sch Med, Dept Lab Med, New Haven, CT USA Yale Univ, Sch Med, AIDS Program, Infect Dis Sect,Dept Internal Med, New Haven, CT USA Yale Univ New Haven CT USA Dis Sect,Dept Internal Med, New Haven, CT USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 3, volume: 24, anno: 2000,
pagine: 241 - 248
SICI:
1525-4135(20000701)24:3<241:IOMWDA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS INFECTION; INJECTION-DRUG USERS; AIDS-RELATED COMPLEX; ANTIRETROVIRAL THERAPY; POPULATION PHARMACOKINETICS; HIV-INFECTION; DOUBLE-BLIND; ZIDOVUDINE; NEVIRAPINE; PLASMA;
Keywords:
didanosine; stavudine; methadone; drug interaction; pharmacokinetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Rainey, PM Univ Washington, Dept Lab Med, Box 357110, Seattle, WA 98195 USA Univ Washington Box 357110 Seattle WA USA 98195 e, WA 98195 USA
Citazione:
P.M. Rainey et al., "Interaction of methadone with didanosine and stavudine", J ACQ IMM D, 24(3), 2000, pp. 241-248

Abstract

For opiate-dependent injection drug users infected with HIV, methadone therapy may facilitate adherence to complex highly active antiretroviral therapy (HAART) regimens. Current HAART regimens include one or more nucleoside analogues. We investigated the effects of methadone on the pharmacokineticsof the tablet formulation of didanosine (ddI) and of stavudine (d4T) in 17study subjects on stable methadone therapy and in 10 untreated controls. Methadone treatment reduced the measured areas under the time-concentration curve (AUC(0-6)) by 63% for ddI (p = .04) and by 25% for d4T (p = .005) andthe extrapolated AUCs for the full dosing interval (AUC(0-12)) by 57% for ddI (p = .11) and by 23% for d4T (p = .02). Peak drug concentrations (C-max) were reduced by 66% (p = .007) and 44% (p = .001) for ddI and d4T, respectively. The effects on AUC and C-max appeared to result primarily from decreases in bioavailability. Methadone also delayed drug absorption. Trough levels for methadone did not differ significantly from those in historical controls, suggesting that ddI and d4T did not substantially alter methadone disposition. The results suggest that larger doses of the tablet formulationor an alternate formulation may be needed when didanosine is given to study subjects treated with methadone.

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Documento generato il 05/04/20 alle ore 07:08:42