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Titolo:
Nuclear and cytoskeletal translocation and localization of heterotrimeric G-proteins
Autore:
Willard, FS; Crouch, MF;
Indirizzi:
Australian Natl Univ, John Curtin Sch Med Res, Div Neurosci, Mol Signalling Grp, Canberra, ACT 2601, Australia Australian Natl Univ Canberra ACT Australia 2601 rra, ACT 2601, Australia
Titolo Testata:
IMMUNOLOGY AND CELL BIOLOGY
fascicolo: 4, volume: 78, anno: 2000,
pagine: 387 - 394
SICI:
0818-9641(200008)78:4<387:NACTAL>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GTP-BINDING PROTEINS; EPIDERMAL GROWTH-FACTOR; RETROGRADE AXONAL-TRANSPORT; PROSTAGLANDIN E-2 RECEPTORS; CATALYZED ADP-RIBOSYLATION; ADRENAL GLOMERULOSA CELLS; FACTOR-INDUCED ACTIVATION; STRESS FIBER FORMATION; S49 LYMPHOMA-CELLS; RAT-LIVER NUCLEI;
Keywords:
cytoskeleton; G-protein; nucleus; translocation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
102
Recensione:
Indirizzi per estratti:
Indirizzo: Crouch, MF Australian Natl Univ, John Curtin Sch Med Res, Div Neurosci, Mol Signalling Grp, GPO Box 334, Canberra, ACT 2601, Australia Australian Natl Univ GPO Box 334 Canberra ACT Australia 2601 ia
Citazione:
F.S. Willard e M.F. Crouch, "Nuclear and cytoskeletal translocation and localization of heterotrimeric G-proteins", IMM CELL B, 78(4), 2000, pp. 387-394

Abstract

Heterotrimeric GTP-binding proteins (G-proteins) are involved in a diversearray of signalling pathways. They are generally thought to be membrane-bound proteins, which disassociate on receptor activation and binding of GTP. A model to explain this has been proposed, which is often described as 'the G-protein cycle'. The 'G-protein cycle' is discussed in the present paperin relation to evidence that now exists regarding the non-membranous localization of G-proteins. Specifically, the experimental evidence demonstrating association of G-proteins with the cytoskeleton and the nucleus, and the mechanisms by which G-proteins translocate to these sites are reviewed. Furthermore, the possible effector pathways and the physiological function of G-proteins at these sites are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 04:08:14