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Titolo:
The impact of interferon gamma receptor expression on the mechanism of escape from host immune surveillance in hepatocellular carcinoma
Autore:
Nagao, M; Nakajima, Y; Kanehiro, H; Hisanaga, M; Aomatsu, Y; Ko, S; Tatekawa, Y; Ikeda, N; Kanokogi, H; Urizono, Y; Kobayashi, T; Shibaji, T; Kanamura, T; Ogawa, S; Nakano, H;
Indirizzi:
Nara Med Univ, Dept Surg 1, Kashihara, Nara 634, Japan Nara Med Univ Kashihara Nara Japan 634 Surg 1, Kashihara, Nara 634, Japan
Titolo Testata:
HEPATOLOGY
fascicolo: 3, volume: 32, anno: 2000,
pagine: 491 - 500
SICI:
0270-9139(200009)32:3<491:TIOIGR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
IFN-GAMMA; MEDIATED APOPTOSIS; STAT1 PROTEIN; UP-REGULATION; BETA-CHAINS; T-CELLS; FAS; ALPHA; MODULATION; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Nagao, M Nara Med Univ, Dept Surg 1, 840 Shijo Cho, Kashihara, Nara 634, Japan Nara Med Univ 840 Shijo Cho Kashihara Nara Japan 634 a 634, Japan
Citazione:
M. Nagao et al., "The impact of interferon gamma receptor expression on the mechanism of escape from host immune surveillance in hepatocellular carcinoma", HEPATOLOGY, 32(3), 2000, pp. 491-500

Abstract

Interferon gamma (IFN-gamma) plays an important role in host defense mechanism and participates in the progression of chronic liver disease. IFN-gamma exerts its pleiotrophic effects by transcriptional regulation of expression of numerous genes, such as major histocompatibility complex (MHC) class I and Fas, through interaction with IFN-gamma receptor (IFN-gamma-R). Although hepatocytes in normal liver express weak or no IFN-gamma-R, those in acute and chronic liver disease up-regulate its expression. A study using IFN-gamma-R alpha-chain knock-out mice revealed the actions of IFN-gamma on tumor cells as an extrinsic tumor-suppressor mechanism. However, it is unclear whether or how hepatocellular carcinoma (HCC) blocks the signal transduction of IFN-gamma to evade host immune surveillance. We examined the expression of IFN-gamma-R and IFN-gamma-inducible genes in 44 cases with HCC usingreal-time reverse-transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry. In noncancerous liver tissues (n = 38), IFN-gamma-R expression on the cell surface was upregulated in 27 cases. In IFN-gamma-R-negative cases (n = 15), tumor size was larger (P = .032), serum alpha-fetoprotein (AFP) level was higher (P = .001), intrahepatic and extrahepatic metastasis was more common (P = .044 and .013, respectively), and Ki-67 labeling index (LI) was higher (P = .041), compared with IFN-gamma-R-positive cases. Accordingly, the evasion mechanism may play an important role in progression, especially metastasis, in HCC. The significant correlation between the status of IFN-gamma-R and the expression of Fas and MHC implies that the loss of IFN-gamma-R might contribute to the mechanism of escape from host immune rejection in HCC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:17:54