Catalogo Articoli (Spogli Riviste)


Coronary heart disease incidence in northern and southern European populations: a reanalysis of the seven countries study for a European coronary risk chart
Menotti, A; Lanti, H; Puddu, PE; Kromhout, D;
Assoc Cardiac Res, I-00198 Rome, Italy Assoc Cardiac Res Rome Italy I-00198 oc Cardiac Res, I-00198 Rome, Italy Univ Minnesota, Div Epidemiol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 demiol, Minneapolis, MN 55455 USA Natl Inst Publ Hlth & Environm, Div Publ Hlth Res, NL-3720 BA Bilthoven, Netherlands Natl Inst Publ Hlth & Environm Bilthoven Netherlands NL-3720 BA herlands
Titolo Testata:
fascicolo: 3, volume: 84, anno: 2000,
pagine: 238 - 244
coronary heart disease; risk factors; risk estimate;
Tipo documento:
Settore Disciplinare:
Clinical Medicine
Life Sciences
Indirizzi per estratti:
Indirizzo: Lanti, H Assoc Cardiac Res, Via Adda 87, I-00198 Rome, Italy Assoc CardiacRes Via Adda 87 Rome Italy I-00198 198 Rome, Italy
A. Menotti et al., "Coronary heart disease incidence in northern and southern European populations: a reanalysis of the seven countries study for a European coronary risk chart", HEART, 84(3), 2000, pp. 238-244


Objective-A systematic reanalysis of 10 year coronary heart disease incidence data from the northern and the southern European cohorts of the seven countries study, to contribute indirectly to the production of a European coronary risk chart. Design and setting-Men aged 40-59 years at entry were studied in three northern European cohorts based in Finland and Netherlands (n = 2213); and in 10 southern European cohorts based in Italy, former Yugoslavia, and Greece (n = 5897). Multiple logistic models for the prediction of coronary deaths, coronary incidence hard criteria), and coronary incidence (any criterion) were solved for the two geographical groups and their pool. Risk factors fed into the models were age, systolic blood pressure, serum total cholesterol, and cigarette smoking. Results-10 year coronary heart disease mortality and incidence were higher in northern than in southern Europe, with ratios around 2.65. Ratios among the three coronary heart disease manifestations were identical in the two cultural groupings. Coefficientsof the multiple logistic models were similar and not significantly different between the two groupings. When applying the coefficients back to the same or the opposite population, the relative risk was large and similar in the different cultures. Relative risk was larger for more severe coronary heart disease manifestations. The absolute risk was overestimated when applying the northern European model to southern European populations and vice versa, with ratios of about 1.5 and 0.5, respectively. Coronary risk charts created to reproduce the shape of these incorporated in recent European guidelines confirmed the excess of absolute risk in the northern compared with the southern European cohorts, all else being equal. Conclusions-In theory,a more appropriate European coronary risk chart could be produced by adopting coefficients to correct for different background incidence rates in different cultures. Other coefficients could appropriately be used to transform mortality risk into incidence risk. (Heart 2000,84:238-244)

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:43:12