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Titolo:
Acute spiral ganglion lesions change the tuning and tonotopic organizationof cat inferior colliculus neurons
Autore:
Snyder, RL; Sinex, DG; McGee, JD; Walsh, EW;
Indirizzi:
Univ Calif San Francisco, Epstein Lab, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Arizona State Univ, Dept Speech & Hearing Sci, Tempe, AZ 85287 USA ArizonaState Univ Tempe AZ USA 85287 & Hearing Sci, Tempe, AZ 85287 USA Boys Town Natl Res Hosp, Omaha, NE 68131 USA Boys Town Natl Res Hosp Omaha NE USA 68131 Res Hosp, Omaha, NE 68131 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 147, anno: 2000,
pagine: 200 - 220
SICI:
0378-5955(200009)147:1-2<200:ASGLCT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
COCHLEAR HEARING-LOSS; RECEPTIVE-FIELD REORGANIZATION; PRIMARY SOMATOSENSORY CORTEX; LATERAL THALAMIC NUCLEUS; BAT AUDITORY-SYSTEM; ADULT FLYING-FOX; DIGIT AMPUTATION; RESTRICTED DEAFFERENTATION; TOPOGRAPHIC REORGANIZATION; PERIPHERAL DEAFFERENTATION;
Keywords:
plasticity; inferior colliculus; hearing loss; tonotopic reorganization; cochlear lesion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Snyder, RL Univ Calif San Francisco, Epstein Lab, POB 0526,U490, San Francisco, CA 94143 USA Univ Calif San Francisco POB 0526,U490 San Francisco CA USA 94143
Citazione:
R.L. Snyder et al., "Acute spiral ganglion lesions change the tuning and tonotopic organizationof cat inferior colliculus neurons", HEARING RES, 147(1-2), 2000, pp. 200-220

Abstract

Many studies have reported plastic changes in central auditory frequency organization after chronic cochlear lesions. These studies employed mechanical, acoustic or drug-induced disruptions of restricted regions of the organof Col ti that permanently alter its tuning and sensitivity and require anextended recovery period before central effects can be measured. In this study, mechanical lesions were made to 1 mm sectors of the spiral ganglion (SG). These lesions remove a restricted portion of the cochlear output, but leave the organ of Corti and basilar membrane intact. Multiunit mapping assessed the pre- and post-lesion tonotopic organization of the inferior colliculus (IC). Immediately after SG lesions, IC neurons previously tuned to the lesion frequencies became less sensitive to those frequencies but more sensitive to lesion edge frequencies, resulting in a shift in their characteristic frequencies (CFs). Notches in the excitatory response areas at frequencies corresponding to the lesion frequencies and expansion of spatial tuning curves were also observed. CFs of neurons tuned to unlesioned frequencies were unchanged. These results suggest that 'plastic' changes similar to those observed after long survival times in previous studies require little or no experience and occur within minutes to hours following the lesion. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:43:11